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Last Updated On: June 7, 2024

Durolane Side Effects: What Can Go Wrong?

Published on: May 8, 2024

According to recent studies, osteoarthritis, one of the most common forms of arthritis, affects approximately 10% of men and 18% of women over 60. As a result, patients often seek relief through various treatments, including intra-articular injections, because of the fewer risks associated with this kind of treatment.

Durolane has become a non-surgical option for managing osteoarthritis symptoms. Administered directly into the affected joint, Durolane lubricates and cushions the joint, relieving pain and discomfort. Unlike traditional corticosteroid injections, which may offer short-term relief, Durolaneā€™s effects can last up to six months.

In this article, we will delve into the potential side effects associated with Durolane, such as localized pain or swelling at the injection site, and other more serious considerations.

Key Takeaways

  • Learn about common side effects like injection site pain, swelling, redness, and rare but serious reactions such as allergic responses.
  • Be aware of signs of severe allergic reactions, such as difficulty breathing, facial swelling, or hives, that require immediate medical attention.
  • Discover tips for managing mild side effects at home, such as applying ice to the injection site for swelling or taking over-the-counter pain relievers for discomfort.
  • Understand the importance of open communication with your healthcare provider. Report any unusual or severe symptoms promptly to ensure timely medical intervention.
  • While many patients experience symptom relief, understand that individual responses to Durolane can vary. Discuss treatment expectations and follow-up plans with your doctor to maximize the benefits of your therapy.

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Common Side Effects of Durolane Knee Injections

Durolane knee injections are effective but can cause side effects. Pain or redness at the injection site is common, usually lasting up to 48 hours. According to some Durolane knee injection reviews, some patients may experience headaches and joint stiffness, indicating the body’s reaction. Most side effects are not serious and resolve on their own. If they persist or worsen, consult a doctor promptly.


Systemic Reactions

Durolane knee injections can trigger systemic reactions, affecting various body parts beyond the knee. Patients may experience headaches, sleep disturbances, and dizziness. Nausea, vomiting, itching, and loss of appetite are also reported. 

Monitoring for these signs is crucial for early intervention and optimal patient care. Educating patients about potential side effects is essential for informed decision-making and timely medical assistance.

Rare Adverse Reactions Associated with Durolane

Durolane knee injections can occasionally lead to rare yet significant side effects that require prompt attention to ensure patient safety. These may include skin or joint infections, noticeable discoloration at the injection site, or decreased sodium hyaluronate levels in osteoarthritic joints. Educating patients about these potential risks is essential for informed decision-making and proactive management of adverse events. 

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Early Recognition and Management of Durolane Side Effects

Spotting and handling Durolane side effects early makes a big difference. Local reactions are a common side effect of Durolane knee injections. Medical professionals need to know how to spot them quickly. Here is a simple guide:

  • Look for redness at the injection site. This shows up as a bright or dark patch on the skin.
  • Check if the area around the injection is warm. Warmth can mean the body is reacting to the injection.
  • Notice any swelling. Swelling might be slight or big, making the knee look more extensive than usual.
  • Watch out for pain in the knee. Patients often feel sore right where they got their shot.
  • Mild pain may come with stiffness in the knee, too. The joint might not move as quickly.
  • Some people also report itching around where they got injected.
  • A headache or feeling stiff all over can happen after a Durolane shot.
  • In rare cases, large blue or purplish patches appear on the skin near the knee.

Managing Systemic Reactions

Systemic reactions from Durolane knee injections can vary from person to person. Some patients may feel sick, get headaches, or have skin itching. Here are ways medical professionals can manage these reactions:

  • Watch for signs of diarrhea, nausea, or vomiting. These common side effects need quick action. Keep patients hydrated and consider anti-nausea medicine if required.
  • Be on the lookout for headaches. If you experience one, advise resting in a quiet, dark room and taking over-the-counter pain relief like acetaminophen.
  • Respond to skin itching with care. Recommend over-the-counter antihistamines to ease discomfort. Tell patients to avoid scratching the itchy area to prevent further irritation.
  • Address loss of appetite by advising small, frequent meals instead of large ones. This approach can help maintain nutrition during this period.
  • Monitor symptoms closely; even mild ones could worsen or signal more serious issues.
  • Educate patients on what sensations they might experience after a Durolane injectionā€”like increased sweating or dizzinessā€”and reassure them about what’s normal versus when to seek help.
  • If any patient reports feeling dizzy or has trouble sleeping, suggest lowering caffeine intake and establishing a soothing bedtime routine for better sleep quality.

Addressing Serious Adverse Events

Serious adverse events from Durolane knee injections are rare but can be concerning. Medical professionals must know how to manage these issues if they arise.

  • Skin or knee joint infections need immediate attention. Doctors should immediately advise patients to report any signs of infection, like increased redness, pain, or fever. Treatment may involve antibiotics or other medications.
  • Large blue or purplish patches on the skin indicate a severe reaction. When patients notice such symptoms, they should be instructed to contact their healthcare provider for an evaluation.
  • Problems at the injection site, including severe pain, swelling, or heat, should prompt a quick assessment for possible allergic reactions or infection. In some cases, cold packs and elevation might help while assessing the need for further medical intervention.
  • Loss of appetite and general illness feelings after a Durolane injection could suggest systemic reactions. Such instances require thorough investigation to rule out serious complications.
  • Diarrhea and nausea/vomiting after receiving Durolane may alarm patients due to discomfort and potential dehydration risks. Advise them to stay hydrated and consult their doctor if symptoms persist beyond a day or two.
  • Heartburn, dizziness, and trouble sleeping are less common but can affect patient well-being post-injection. Providing advice on managing these side effects at home is crucial, with follow-up if problems continue.
  • For those experiencing increased sweating and acne following an injection, doctors might recommend simple skincare routines to help manage these side effects until they resolve naturally.

Recommendations for Patient Monitoring and Safety

Monitoring patients after a Durolane knee injection ensures their safety and comfort. This step is crucial for catching any side effects early. Here’s how medical professionals can effectively monitor their patients:

  • Schedule a follow-up appointment to monitor progress and address concerns.
  • Advise patients to report pain, swelling, or warmth at the injection site within the first 48 hours.
  • Monitor for signs of skin or knee joint infections like redness, heat, or pus.
  • Educate patients about recognizing side effects such as blue skin patches or increased knee pain.
  • Recommend keeping a symptom diary to track post-injection feelings for future reference.
  • Watch for systemic reactions such as diarrhea, headache, or nausea following the injection.
  • Evaluate the patient’s overall health and any new symptoms unrelated to their knee.
  • Inform patients about potential long-term effects like reduced sodium hyaluronate in joints.
  • Allow patients to walk after the injection, but advise on activity restrictions based on their reaction.

Patient Education and FollowUp

Patient education and follow-up are essential after a Durolane knee injection. This helps patients know what to expect and how to care for themselves.

  • Explain the Common Side Effects: Start by letting patients know they might feel pain, warmth, or swelling at the injection site. Some may also have headaches or joint stiffness.
  • Warn About Serious Side Effects: Ensure patients understand the signs of infections or large blue skin patches requiring immediate medical attention.
  • Discuss Long-term Expectations: Inform them that Durolane can relieve pain but may reduce sodium hyaluronate in joints over time.
  • Advise on Activity Post-injection: Patients often ask, “Can you walk after a Durolane injection?” Yes, but they should avoid heavy activities for a couple of days.
  • Schedule a Follow-up Visit: Set an appointment to check their knee’s condition and discuss concerns.
  • Provide Contact Information: They can contact you if they have urgent questions or notice severe side effects.
  • Educate on Multiple Injections: Talk about success rates and when another infusion might be needed.
  • Address Cost Concerns: Be upfront about expenses, which can affect their decision-making process.


Durolane knee injections are generally well-tolerated, but healthcare providers must be aware of potential side effects and prepared to manage them effectively. By recognizing early signs of adverse reactions, implementing appropriate management strategies, and closely monitoring patients, healthcare professionals can ensure the safety and well-being of individuals receiving Durolane injections for knee osteoarthritis.


1. What is Durolane, and why do people use it?

Durolane is an injection used to relieve knee pain caused by arthritis. Patients opt for Durolane to reduce pain and improve knee mobility.

2. Can you walk after getting a Durolane injection?

Absolutely! Most patients can walk immediately after receiving a Durolane injection. However, for safety, it’s wise to follow your doctor’s advice on post-injection activity levels.

3. How does Durolane compare with Synvisc?

Durolane and Synvisc are both injections for knee arthritis pain relief. Some prefer Durolane for its longer-lasting effects, while others favor Synvisc. The choice between them depends on individual patient response.

4. What side effects should I watch out for after a Durolane shot?

After a Durolane injection, watch for common side effects such as swelling or soreness at the injection site. Less common side effects might include knee stiffness or increased pain, which should prompt a discussion with your doctor.

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DeJulius CR, Gulati S, Hasty KA, Crofford LJ, Duvall CL. Recent Advances in Clinical Translation of Intraā€Articular Osteoarthritis Drug Delivery Systems. Advanced therapeutics. 2020;4(1). doi:

Migliore A, Picarelli G. Is osteoarthritis a gender-specific disease? Journal of Sex- and Gender-Specific Medicine. 2018;4(1):13-20.