Liztox dilution chart
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Last Updated On July 1, 2024

Liztox Dilution Chart – Information for Practitioners

Jun 7, 2024

A recent Phase 3 clinical trial has highlighted the efficacy and safety of Liztox, a botulinum toxin injection, in managing post-stroke upper limb spasticity. This study marks a significant milestone in applying botulinum toxin type A (BTX-A) for therapeutic interventions, showcasing Liztox as a viable alternative to Botox.

When administering injections like Liztox, it’s crucial to follow the Liztox dilution chart to achieve optimal clinical outcomes. This chart serves as a critical reference for practitioners, ensuring the correct dosage is administered for each case, thus maximizing patient recovery and comfort.

In this article, we will examine the Liztox dilution chart in detail, providing practitioners with a comprehensive guide to optimize the use of Liztox in their clinical practice.

Key Takeaways

  • For beauty treatments, like fixing wrinkles or making lips bigger, doctors mix 100 units of Liztox with 2.5ml saline. This helps the treatment work well.
  • Special mixing rules exist when treating health problems like tight muscles or too much sweat. This ensures that the treatment is strong enough to help but still safe.
  • Keeping mixed Liztox cold in the fridge keeps it working right. It should be used within 24 hours or thrown away.
  • Doctors need to learn how to use Liztox safely. They need to know what problems to look out for and how to fix them quickly if they occur.

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Introduction to Liztox Dilution Chart

Liztox requires precise handling, starting with its proper dilution. It is a botulinum toxin type A, similar to Botox and Xeomin, that comes in 100-unit vials and is mixed with 0.9% saline before doctors use it on patients. Its form is a clear, colorless bottle filled with white freeze-dried powder.

Practitioners must turn it into a solution by following concrete steps for safety and effectiveness. The key to this process is following the Liztox dilution chart, which guides medical experts through correct dilution ratios to determine whether they are smoothing fine lines or managing muscle spasticity.

Achieving the perfect dilution for fine lines and wrinkles, facial contouring, and lip augmentation is crucial for optimal results. The right balance of dilution ratios ensures safe and effective aesthetic treatments.

  • Dilution Ratio for Treating Fine Lines and Wrinkles: To treat fine lines and wrinkles with Liztox, mix 2.5 ml of saline per 100 units. This precise dilution ensures each 0.1 ml injection is effective, providing smoother skin and minimizing side effects. 
  • Dilution Ratio for Facial Contouring: When aiming for facial contouring, it’s important to note that a recommended dilution ratio would typically involve 100 units of Liztox diluted with around 2.5ml of saline solution. 
  • Dilution Ratio for Lip Augmentation: For lip augmentation with Liztox, mix 100 units with 2.5ml of saline. This ensures each 0.1ml injection is precise and effective.

Use the appropriate dilution ratio to treat muscle spasticity. A specific dilution ratio is recommended for managing chronic migraines and hyperhidrosis.

  • Dilution Ratio for Treating Muscle Spasticity: To treat muscle spasticity with Liztox, dilute 100 units with 4 ml of preservative-free saline, resulting in 25 units per ml. This precise ratio ensures effective treatment and optimal therapeutic outcomes.
  • Dilution Ratio for Managing Chronic Migraines: To manage chronic migraines with Liztox, dilute 100 units with 2.5 ml of 0.9% saline. This ensures each injection site receives the correct dosage, which has proven effective in trials. 
  • Dilution Ratio for Hyperhidrosis Treatment: For hyperhidrosis treatment with Liztox, dilute 100 units with 2.5 ml of preservative-free saline. This ensures precise treatment, with each injection site receiving 0.1ml of solution. 

Preparation Process for Liztox

To properly reconstitute Liztox, mix 2.5 ml of nonpreserved sterile saline with the freeze-dried powder in the 100-unit vial, resulting in a dilution ratio of 4 units per 0.1 ml. Gently swirl the vial to dissolve the powder, avoiding vigorous shaking to prevent foaming or denaturation. 

After dissolution, inspect for particulate matter or discoloration, ensuring the solution is clear and colorless before administration. For Liztox 200 units, use 4ml of saline for dilution, maintaining the same saline concentration for effectiveness and patient safety.

Following these guidelines meticulously prevents contamination and promotes safe administration practices. Upholding strict sterilization methods and precise reconstitution ensures Liztox’s integrity and effectiveness, safeguarding against potential risks during the preparation process.

Storage Guidelines for Diluted Liztox

Store diluted Liztox between 2°C and 8°C in a refrigerator, shielding it from light and freezing. Use it within 24 hours of reconstitution with saline, or discard any leftovers. Failure to adhere to these guidelines can reduce its efficacy. Maintaining proper storage conditions is essential for Liztox’s potency. Follow these steps to ensure its effectiveness between injections. 

After dilution, use Liztox within 24 hours and store it in the fridge. Discard any unused solution to guarantee patient safety. Handle it carefully and store it as recommended to prevent contamination and degradation. Strict adherence to storage protocols is crucial for preserving Liztox’s stability and potency until administration.

Administration Techniques for Diluted Liztox

Achieving optimal aesthetic results with Liztox relies on precise injection techniques and site selection. To treat fine lines, target the orbicularis oculi muscle. Contouring injections focus on the jawline and chin, while lip augmentation requires injections along the vermilion border and philtrum. 

Tailoring injections to specific sites enhances facial aesthetics and ensures patient satisfaction. Dilution techniques impact dosage and aesthetic outcomes, underscoring the importance of precise injections aligned with treatment goals for optimal patient benefit.

Administering Liztox for therapeutic purposes demands precision in injection sites and techniques. For muscle spasticity, inject 2.5-3 units per affected muscle with careful site selection. Chronic migraine management involves injecting 155 units across head and neck muscles following a defined pattern. 

Patient Assessment and Aftercare Instructions

For patient assessment, gather medical history and allergies and assess muscle strength and skin condition. Aftercare includes avoiding rubbing or massaging treated areas for at least four hours, no strenuous exercise on treatment day, and no excessive sun exposure or extreme temperatures for 24 hours. Thorough assessment ensures safe Liztox administration and optimal results.

Clinical Guidelines and Expert Recommendations for Liztox Dilution

Clinical trials, such as those about Liztox vs. Xeomin‘s safety and efficacy, attest in medical practice and provide robust evidence for its diverse aesthetic and therapeutic uses. Healthcare providers should integrate these findings to optimize patient outcomes, emphasizing adherence to recommended dilution ratios and administration techniques. 

Following these guidelines, practitioners enhance treatment precision and minimize risks associated with botulinum toxin injections. Incorporating insights from clinical trials empowers providers to deliver safe and effective Liztox treatments guided by expert recommendations tailored to specific medical applications.

Safety Considerations and Adverse Event Management

Safety is paramount with Liztox. Practitioners must be vigilant about adverse events and their management. Proper training enables quick recognition and action. Understanding signs like allergic reactions or muscle weakness ensures patient safety. 

Having an emergency plan and knowing procedures for managing adverse events is crucial. Documenting events aids in evaluating Liztox’s safety profile. Staying updated on safety recommendations ensures optimal patient care while minimizing risks.


Liztox is essential for practitioners, with dilution ratios pivotal for patient safety and treatment effectiveness. Adhering to reconstitution and storage guidelines ensures optimal results. Expert advice and clinical insights enhance practitioners’ understanding of Liztox dilution, contributing to its safe and effective use.


1. What distinguishes Liztox from Xeomin? 

Liztox and Xeomin are distinct brands used in the cosmetic industry for wrinkle smoothing. Although they share similar functions, they originate from separate manufacturers.

2. How can I determine the suitability of Liztox versus Botulax for my patients? 

Selecting between Liztox and Botulax hinges on individual patient requirements, with varying responses to each treatment. 

3. Is there a dedicated dilution chart available for Liztox? 

Indeed, specific dilution charts exist to guide the precise mixing of Liztox. These charts provide instructions for achieving an optimal blend and balancing potency without compromising safety.

4. Are there notable distinctions in the preparation of Liztox compared to Xeomin or Botulax? 

Preparation procedures for Liztox, Xeomin, and Botulax are largely similar. Attention to detail and adherence to the recommended dilution chart are paramount. Following these guidelines meticulously ensures the accurate preparation of each product.

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Ye DH, Chun MH, Park YG, et al. A Randomized, Double-Blind, Active Control, Multicenter, Phase 3 Study to Evaluate the Efficacy and Safety of Liztox® versus Botox® in Post-Stroke Upper Limb Spasticity. Toxins. 2023;15(12):697. doi:

The Dilution Confusion: Easy Dosing for Botulinum Toxins.