SHARE THIS ARTICLE
Euflexxa
Euflexxa vs Synvisc – Comparing OA Treatments
Oct 10, 2024
A sedentary lifestyle, combined with a poor diet and lack of physical activity, can increase the risk of developing osteoarthritis (OA). According to the CDC, more than 32.5 million adults in the U.S. suffer from OA, a degenerative joint condition that causes pain, swelling, and limited mobility.
Euflexxa and Synvisc are two injectable treatments designed to relieve knee pain caused by osteoarthritis. Both treatments use hyaluronic acid to lubricate the joint and improve movement, but they differ in formulation, duration of relief, and patient suitability.
In this article, we will compare Euflexxa vs Synvisc, highlighting their differences, benefits, and how they can help patients manage knee osteoarthritis effectively.
Key Takeaways
- Euflexxa and Synvisc are both hyaluronic acid-based viscosupplements designed to relieve knee pain caused by osteoarthritis.
- Euflexxa requires three injections over several weeks, while Synvisc offers flexible options, including a single injection or three smaller injections.
- Both treatments provide lubrication and cushioning for the joints, improving mobility and reducing pain, with similar efficacy and safety profiles.
- Euflexxa is often preferred for those seeking long-term relief and delaying knee replacement, while Synvisc offers more flexible injection schedules.
- Patients should consult with their healthcare providers to determine the best treatment option based on their medical condition and insurance coverage.
About: Trusted by over 2,000+ global clients since 2014, Maylips has become a leading supplier of cosmetic, skincare, and orthopedic products for medical and aesthetic professionals. Maylips offers a wide range of authentic brand-name products at competitive wholesale prices, sourced from around the world. If you’re looking to buy Euflexxa online, contact our sales team for guidance.
Understanding Osteoarthritis and Viscosupplements
Osteoarthritis is a common degenerative joint condition that progressively wears down the cartilage, leading to pain, stiffness, and limited mobility. It primarily affects weight-bearing joints like the knees and hips, making daily movements uncomfortable and difficult. As the cartilage deteriorates, the bones rub against each other, causing increased pain and inflammation.

To help manage these symptoms, viscosupplements are used in osteoarthritis treatment. These injectable treatments contain hyaluronic acid, a substance that mimics the body’s natural joint fluid, enhancing lubrication and cushioning within the joint. By reducing friction between the bones, viscosupplements help alleviate pain, improve movement, and, in some cases, delay the need for knee replacement surgery.
Euflexxa
Euflexxa is a viscosupplement treatment designed to relieve osteoarthritis pain through a series of injections. It is composed of hyaluronic acid, a naturally occurring substance in the body that helps lubricate and cushion the joints. Key benefits of Euflexxa include:

- Reducing joint swelling and inflammation
- Improving movement and flexibility
- Providing essential cushioning between joints
- Acting as a lubricant and shock absorber within the joint
The standard treatment involves three injections over several weeks. Euflexxa works by replenishing the synovial fluid, which helps renew the joint’s natural lubrication and makes movement easier and less painful.
Synvisc
Synvisc is a viscosupplement treatment designed to mimic the body’s natural joint fluid, providing essential cushioning and lubrication to relieve pain caused by osteoarthritis. The key component in Synvisc is hyaluronic acid (sodium hyaluronate), a substance naturally found in healthy joints that helps maintain smooth movement and reduce friction. Key features include:
- Contains hyaluronic acid (sodium hyaluronate) for joint lubrication
- Acts as a lubricant and shock absorber
- Helps joints move smoothly by increasing fluid in the joint
Synvisc offers flexible injection schedules, ranging from a single injection to a series of three injections, depending on the patient’s needs. Many patients report significant pain relief after treatment, and in some cases, it can help delay the need for knee replacement surgery.
Comparing Euflexxa and Synvisc
In a multicenter, randomized, double-blind study involving 321 patients with chronic knee osteoarthritis, Euflexxa’s efficacy and safety was evaluated. The results showed that Euflexxa significantly relieved pain and improved joint function over 12 weeks.

When compared with Synvisc in another 12-week, double-blind study involving patients with stage 2-3 knee osteoarthritis. This study found that both treatments were similarly safe and effective.
Safety Profile and Side Effects of Euflexxa vs Synvisc
Both treatments are generally considered safe. Common Euflexxa side effects include pain, swelling, and heat in the knee following injections. Synvisc has a similar safety profile, with side effects such as temporary swelling and discomfort at the injection site. However, more severe side effects, like allergic reactions or infections, are rare for both treatments.
Treatment Protocols and Administration of Euflexxa and Synvisc
Euflexxa requires a series of three injections, administered one week apart, for optimal results. Synvisc offers more flexibility, with the option of a single large injection or three smaller ones over several weeks, depending on the patient’s condition.
Before either treatment, the doctor may remove excess fluid from the knee to make room for the new injection. A sterile technique minimizes the risk of infection, and patients are advised to avoid heavy activities for 48 hours after each shot.
Cost Comparison of Euflexxa and Synvisc
When comparing the costs of Euflexxa vs Synvisc, factors such as insurance coverage, the number of injections required, and the type of treatment plan should be considered. Euflexxa typically requires three injections over several weeks, while Synvisc offers flexibility with either one or three injections.
Conclusion
Choosing between Euflexxa and Synvisc for knee osteoarthritis treatment depends on individual preferences and medical needs. While both treatments effectively relieve pain and improve mobility, Euflexxa may appeal to those looking for long-term relief and the potential to delay knee replacement. In contrast, Synvisc offers more flexibility in its injection schedule.
Consulting with a healthcare provider is essential to determine the best option based on your specific health condition and insurance coverage.
FAQs
1. How long does relief from Euflexxa and Synvisc last?
Both Euflexxa and Synvisc can provide relief from knee pain for up to six months, depending on the severity of the osteoarthritis and individual patient response.
2. Are there any side effects associated with Euflexxa and Synvisc?
Both treatments have similar safety profiles. Common side effects include pain, swelling, and heat at the injection site. Serious side effects, such as infection or allergic reactions, are rare.
3. Which treatment is more cost-effective, Euflexxa or Synvisc?
The cost of Euflexxa vs Synvisc depends on factors such as insurance coverage, the number of injections required, and the specific treatment plan. Patients should discuss their options with their healthcare provider and insurance company to determine the most cost-effective choice.
References
NIAMS health information on osteoarthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. Published December 15, 2023. https://www.niams.nih.gov/health-topics/osteoarthritis
Centers for Disease Control and Prevention. Osteoarthritis. Published January 26, 2024. https://www.cdc.gov/arthritis/osteoarthritis/
Huffman KF, Ambrose KR, Nelson AE, Allen KD, Golightly YM, Callahan LF. The critical role of physical activity and weight management in knee and hip osteoarthritis: A narrative review. The Journal of Rheumatology. 2023;51(3):jrheum.2023-0819. doi:https://doi.org/10.3899/jrheum.2023-0819