Euflexxa prescribing information
Euflexxa
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Last Updated On October 17, 2024

Euflexxa Prescribing Information

Oct 14, 2024

A recent study published in PLOS ONE investigated the causal relationship between diet and knee osteoarthritis (OA), suggesting that certain dietary factors may significantly influence the development and progression of the condition. 

Given the impact of lifestyle on OA, patients need to explore all treatment options, including Euflexxa. This viscosupplement is indicated for patients with knee OA who have not responded adequately to conservative non-pharmacologic therapy and simple analgesics. Understanding the prescribing information for Euflexxa is crucial for patients and healthcare providers as they consider comprehensive management strategies for knee OA.

In this article, we will explore the Euflexxa prescribing information, including its indications, dosage, administration, and potential side effects, to help you make an informed decision.

Key Takeaways

  • Euflexxa is an injectable treatment used to relieve knee pain in adults with osteoarthritis, particularly when other treatments fail. It contains sodium hyaluronate, which mimics the body’s natural joint fluid.
  • Euflexxa provides lasting pain relief for osteoarthritis patients, improving mobility and quality of life when used as part of a comprehensive treatment plan.
  • Euflexxa is typically given in three injections spaced one week apart, with each injection containing 2 mL of sodium hyaluronate.
  • Euflexxa is not recommended for individuals allergic to bird proteins, feathers, or egg products, and it is unsuitable for children, pregnant or breastfeeding women, or those with active knee infections.
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What is Euflexxa?

Euflexxa is an injectable treatment designed to alleviate knee pain in adults with osteoarthritis, especially when other remedies fail. The Euflexxa generic name, sodium hyaluronate, refers to the highly purified hyaluronan solution used in the injections. Administered directly into the knee joint, Euflexxa typically requires three injections, spaced one week apart.

While not recommended for children, adults who do not experience relief from simple analgesics may benefit significantly from Euflexxa. For those considering this treatment, understanding the dosage and injection frequency of Euflexxa is essential in deciding the best relief for osteoarthritis.

Dosage Recommendations

The proper dosage of Euflexxa is essential for effective knee pain relief. Doctors typically administer three 2 mL injections directly into the affected knee joint, once a week for three weeks. This regimen helps alleviate knee pain from osteoarthritis in adults who have not found relief with basic painkillers. 

Euflexxa is unsuitable for children and should be used exclusively for knee pain. Adhering to this injection schedule is crucial for managing symptoms effectively, allowing patients to experience improvement without relying on additional medications. Following the prescribed plan ensures optimal results for those suffering from osteoarthritis-related discomfort.

Administration Routes

Euflexxa is not administered intravenously. It is specifically formulated for intra-articular injections, meaning it is injected directly into the knee joint. This method ensures the hyaluronic acid is delivered to the area where it is most needed, providing targeted pain relief and lubrication to the joint affected by osteoarthritis.

The standard procedure involves the following steps:

  • Sterilization: The injection site is sterilized with an antiseptic solution to reduce the risk of infection.
  • Aspiration: Sometimes, excess fluid may be removed from the knee joint (aspiration) before injecting Euflexxa, which makes space for the new fluid and helps reduce discomfort.
  • Injection: Using an 18- to 22-gauge needle, the physician carefully injects the 2 mL Euflexxa solution into the knee joint space. The injection is done slowly and precisely to ensure even distribution.
  • Post-Injection Care: After the injection, patients are usually advised to rest the knee and avoid strenuous activities for 48 hours to help with recovery and ensure the effectiveness of the treatment.

Contraindications and Safety Considerations

Before using Euflexxa, it is key to know who should avoid it and the possible risks. This includes listing patients not suitable for it, its side effects, and how to use it safely.

  • Individuals allergic to bird proteins, feathers, or egg products should avoid Euflexxa due to potential allergic reactions.
  • Patients with infections or skin conditions near the injection site should refrain from using Euflexxa to prevent complications.
  • Euflexxa is not recommended for children, as its safety and effectiveness in younger populations are unproven.
  • Those with bleeding disorders should avoid Euflexxa, as it may exacerbate their condition.
  • Pregnant women or those planning pregnancy should consult their doctor before considering Euflexxa due to unknown effects on unborn babies.
  • Breastfeeding mothers should also discuss potential risks with healthcare professionals.
  • Patients with severe knee swelling or infections should wait until these issues are resolved before using Euflexxa.
  • Anyone scheduled for knee surgery should consult their doctor about the timing of Euflexxa injections.

Understanding these restrictions ensures the safe and effective use of Euflexxa to manage osteoarthritis knee pain without unexpected side effects or adverse reactions related to Euflexxa side effects or contraindications.

Potential Side Effects and Adverse Reactions

Patients receiving Euflexxa may experience side effects such as pain, swelling, or redness at the injection site. Some might feel heat in the knee or have difficulty walking comfortably afterward. Rarely, serious issues like joint infections can occur. 

Medical professionals should monitor for allergic reactions, which may manifest as hives, facial swelling, or difficulty breathing and require immediate attention. Additionally, Euflexxa should not be used in children or administered intravenously. Patients should avoid heavy activities for 48 hours post-injection to allow their knees time to adjust.

Conclusion

Euflexxa offers effective relief for knee osteoarthritis when other treatments have not provided adequate results. Administered as a series of three injections over three weeks, it helps reduce pain and improve mobility. However, understanding its contraindications and potential risks is essential for safe use.

While unsuitable for children, Euflexxa can significantly improve the quality of life for adults suffering from osteoarthritis when administered properly and under medical guidance.

FAQs

1. What is the typical dosage for Euflexxa?

The typical dosage for Euflexxa is 2 mL injected intra-articularly into the affected knee once a week for 3 to 5 weeks

2. Who should avoid Euflexxa?

Individuals allergic to bird proteins, feathers, or egg products, those with infections or skin conditions near the injection site, patients with bleeding disorders, and pregnant or breastfeeding women should avoid Euflexxa.

3. What common side effects should patients expect?

Common side effects include injection site pain, swelling, and temporary worsening of knee pain.

4. Can Euflexxa be combined with other treatments?

Yes, but patients should consult their healthcare provider within two weeks to ensure safe use and avoid other knee injections.

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References

Xiaofeng Lv, Liang F, Liu S, et al. Causal relationship between diet and knee osteoarthritis: A Mendelian randomization analysis. PloS one. 2024;19(1):e0297269-e0297269. doi:https://doi.org/10.1371/journal.pone.0297269 

Research C for DE and. Prescribing Information Resources. FDA. Published online January 19, 2023. https://www.fda.gov/drugs/fdas-labeling-resources-human-prescription-drugs/prescribing-information-resources