doctor gently injecting treatment into the knee
Hymovis
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Last Updated On November 25, 2024

Hymovis Injection Ingredients – About HYADD4

Nov 21, 2024

Hyaluronic acid (HA) is a naturally occurring substance in the body that helps lubricate and cushion the joints. Recent studies have shown that HA injections can be effective in treating osteoarthritis, providing relief from pain and improving joint function.

Hymovis is an advanced injectable treatment for knee osteoarthritis. It utilizes HYADD®4, a unique, highly viscoelastic form of hyaluronic acid, to provide prolonged relief and improve joint mobility.

In this article, we will explore the ingredients of Hymovis, focusing on HYADD®4, to understand how it contributes to joint health and pain management.

Key Takeaways

  • Hymovis injections use HYADD®4, a modified high-molecular-weight hyaluronic acid, to deliver superior joint lubrication and cushioning.
  • HYADD®4 reduces pain, improves joint mobility, and supports cartilage regeneration, addressing both symptoms and underlying joint health.
  • Its resistance to breakdown ensures durability, offering relief for up to six months with just two injections.
  • Hymovis is generally well-tolerated, with only mild and temporary side effects such as swelling or redness at the injection site.
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What is HYADD4?

HYADD®4 is the key component of Hymovis injections, a modified form of hyaluronic acid (HA) designed to provide superior joint lubrication and cushioning for individuals with knee osteoarthritis. Unlike standard HA, HYADD®4 is a high-molecular-weight and viscoelastic compound, giving it unique properties that enhance its efficacy.

checking knee via ultrasound

The molecular structure of HYADD®4 incorporates advanced crosslinking technology, which makes it more resistant to degradation within the joint. This durability allows it to remain effective longer than traditional hyaluronic acid formulations, ensuring prolonged joint lubrication and reduced pain. Its high viscosity and elasticity mimic the natural synovial fluid, restoring smooth movement and protecting the cartilage from wear and tear.

How Does HYADD4 Work in Osteoarthritis Treatment?

Hymovis injections leverage the unique properties of HYADD®4 to address joint issues caused by osteoarthritis. Its advanced formulation closely replicates the natural components of healthy synovial fluid, ensuring optimal lubrication and shock absorption.

administering knee injection to treat osteoarthritis

What sets HYADD®4 apart is its resilience within the joint environment. It enhances joint mechanics by reducing wear and tear on cartilage and mitigating friction between bone surfaces. This protective action not only reduces pain but also supports the long-term health of the joint. Additionally, HYADD®4’s extended duration of action means fewer injections are needed, making it a convenient option for patients seeking sustainable relief.

Benefits of HYADD4 in Hymovis Treatment

The inclusion of HYADD®4 in Hymovis injections brings several distinct benefits for managing knee osteoarthritis:

exercising the knee
  • Effective Pain and Swelling Reduction: HYADD®4 enhances joint lubrication and reduces friction, relieving discomfort and swelling often associated with osteoarthritis.
  • Enhanced Mobility and Joint Function: Acting as a lubricant and shock absorber, HYADD®4 facilitates smoother joint movement and helps patients regain flexibility in their knees.
  • Cartilage Support and Repair: Unlike some treatments, HYADD®4 promotes cartilage regeneration, aiding in tissue repair and fostering healthier, more durable cartilage.
  • Long-Lasting Relief: Patients benefit from fewer injections compared to other hyaluronic acid treatments, with relief lasting several months.
  • Proven Safety Profile: Hymovis injections are generally safe, with only mild and temporary side effects like swelling or redness at the injection site.

The Scientific Basis for Hyadd4’s Effectiveness

The effectiveness of HYADD4 in Hymovis injections is grounded in its unique molecular structure and ability to mimic the natural properties of synovial fluid. Studies have shown that HYADD4 forms a stable hydrogel when injected into the joint to lubricate and protect it.

  • biz..: “I love it! I was getting another injection every six months. Hymovis has been working very well for me. Now I get Hymovis every 12 months.”

Additionally, a multi-centre, open label, long-term follow-up study evaluated the benefits of Hymovis in treating knee osteoarthritis. The study found that two intra-articular injections of Hymovis significantly reduced pain and improved joint function over a period of 52 weeks

  • Anonymous: “I am a 72-year-old woman and recently had my 3rd set of Hymovis shots in my right knee. Had first shots in June of 2021, second in Nov. 2021, and third June 2022. After the first set was given in June 2021, it took about 2 weeks for me to get relief. But since then, I have been virtually pain-free. I had tried physical therapy – no good. Had arthroscopic surgery to remove meniscus – no good. Before knee replacement, my doctor recommended Hymovis shots – and I’m so glad he did! They work for me.”

Furthermore, the MOKHA Study explored the biological and structural effects of Hyadd4 on osteoarthritic knees, finding increased cartilage volume and Type II collagen turnover. These findings highlight Hyadd4’s potential structural benefits, making it a promising non-surgical treatment option for osteoarthritis.

Understanding the Durability of HYADD4 Treatment

Unlike traditional hyaluronic acid formulations, HYADD®4 is chemically modified to resist breakdown within the joint. This means it remains effective for more extended periods, often providing relief from knee osteoarthritis symptoms for up to six months or more.

When comparing Hymovis vs Hyalgan, the durability of HYADD®4 sets Hymovis apart. Hyalgan, while effective, uses low-molecular-weight hyaluronic acid, which may require more frequent injections to maintain results. In contrast, the advanced crosslinked structure of HYADD®4 allows for sustained joint lubrication and cushioning with just two injections, making it a convenient and long-lasting solution for patients.

This enhanced durability not only reduces the need for repeated treatments but also helps patients maintain improved mobility and reduced pain over extended periods.

Conclusion

Hymovis injections, powered by HYADD®4, are an effective solution for managing knee osteoarthritis. Acting as a cushion within the joint, they enhance movement, reduce discomfort, and promote cartilage regeneration. Backed by studies, Hymovis not only alleviates pain but also supports long-term joint health.

With its innovative formula and long-lasting relief, Hymovis stands out as an excellent choice for individuals seeking improved knee function and a better quality of life.

FAQs

1. What makes Hymovis different from other hyaluronic acid injections?

Hymovis uses HYADD®4, a unique, high-molecular-weight hyaluronic acid that provides enhanced lubrication and longer-lasting relief compared to standard formulations.

2. How long do the effects of Hymovis last?

Most patients experience relief for up to six months after completing the two-injection regimen.

3. How does Hymovis promote cartilage regeneration?

HYADD®4 in Hymovis stimulates cartilage repair by reducing friction and encouraging the production of natural hyaluronic acid, supporting joint health over time.

4. Who is a suitable candidate for Hymovis injections?

Patients with knee osteoarthritis who have not responded well to other treatments, such as physical therapy or oral medications, may benefit from Hymovis injections. Consult a healthcare provider to determine suitability.

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References

Hyaluronan V. High Molecular Weight. https://hcp.hymovis.com/wp-content/uploads/sites/2/2023/02/Hymovis-Package-Insert-USA-68573-13-C-June-20211.pdf 

Sendić G. Knee Joint. Kenhub. Published March 3, 2022. https://www.kenhub.com/en/library/anatomy/the-knee-joint