Hymovis vs Hyalgan Differences Explained
Hymovis
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Last Updated On November 25, 2024

Hymovis vs Hyalgan – Differences Explained

Nov 21, 2024

Proper joint movement is crucial for maintaining an active and healthy lifestyle. According to experts, the knee joint is the largest and most stressed joint in the body, playing a vital role in supporting body weight, movement, and balance.

For knee osteoarthritis patients, treatments like Hymovis and Hyalgan offer non-surgical options to alleviate pain and improve joint function. Both products are viscosupplements that inject hyaluronic acid into the affected joint, but they differ in composition, application, and duration of effect.

In this article, we will compare Hymovis vs Hyalgan, examining their differences, benefits, and suitability to help you make an informed decision about your knee health.

Key Takeaways

  • Hymovis features high-molecular-weight hyaluronic acid for enhanced joint lubrication and extended pain relief, while Hyalgan uses low-molecular-weight hyaluronic acid for steady symptom improvement.
  • Hymovis requires only two injections spaced a week apart, while Hyalgan involves a series of three to five weekly injections.
  • Both treatments typically offer pain relief for up to six months, though Hymovis may provide longer-lasting benefits for some patients.
  • Hymovis is ideal for those seeking a shorter treatment schedule, while Hyalgan may suit individuals who prefer a gradual approach or have mild to moderate symptoms.
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Molecular Structure and Composition

Hymovis and Hyalgan both utilize hyaluronic acid (HA) to manage knee osteoarthritis, but their molecular structures set them apart. Hymovis features high-molecular-weight hyaluronic acid (HYADD®4), a unique formulation that provides superior joint lubrication and cushioning. Its dense consistency enhances shock absorption and reduces friction, offering long-lasting relief and smoother knee movement.

ultrasound on the woman's knee

On the other hand, Hyalgan uses low-molecular-weight hyaluronic acid that effectively reduces inflammation and alleviates knee pain. Its lighter formulation improves joint movement and minimizes the formation of scar tissue.

Duration of Effects and Injection Protocols

Hymovis and Hyalgan both aim to reduce knee pain and improve mobility, but their injection protocols and the duration of their effects differ significantly.

Hymovis offers the convenience of a two-injection regimen, with each injection containing 3 mL of solution administered one week apart. Thanks to its high-molecular-weight hyaluronic acid, which provides enhanced joint lubrication and cushioning, patients often experience relief for up to six months. To minimize discomfort and swelling, patients should avoid strenuous activities for at least 48 hours after treatment.

In contrast, Hyalgan requires a series of three injections over 3-5 weeks, with each dose containing 2 mL of solution. While its low-molecular-weight hyaluronic acid delivers effective pain relief, the multi-injection regimen allows for a more gradual improvement. Like Hymovis, patients are advised to rest the knee for 48 hours following each injection to reduce the risk of side effects.

Both treatments offer similar durations of pain relief—typically lasting up to six months—but the choice between them often comes down to patient preference and lifestyle. Hymovis’s shorter regimen may appeal to those seeking a more convenient option, while Hyalgan’s steady approach suits patients who prefer a traditional schedule.

Side Effect Profiles and Clinical Outcomes

Hymovis and Hyalgan are generally well-tolerated viscosupplements, but like any medical treatment, they can cause mild side effects. These typically occur at the injection site and are temporary in nature. When comparing other viscosupplementation treatments (such as Hymovis vs Euflexxa), the side effect profiles are similarly mild, reflecting the overall safety of hyaluronic acid-based injections.

woman standing against the wall while checking her knee

Patients may experience mild swelling, pain, or stiffness in the knee following the injection. Some individuals report redness or warmth around the injection site, but these symptoms usually resolve within a few days. Rare complications, such as infection or severe allergic reactions, are uncommon when administered by a qualified healthcare provider.

Clinical Outcomes

Clinical studies on Hymovis have significantly reduced pain scores and improved cartilage volume and Type II collagen turnover. Specifically, a pivotal trial revealed a 34% reduction in WOMAC/VAS pain scores at six months. Furthermore, long-term follow-up studies have shown substantial pain, stiffness, and physical function improvements.

Similarly, Hyalgan has proven effective in several trials. Notably, a double-blind, placebo-controlled study demonstrated long-lasting pain relief lasting up to six months. Additionally, studies conducted in Asian populations and within multimodal treatment contexts further supported these findings, showing significant improvements in pain and function.

Patient Satisfaction and Considerations for Treatment Selection

Selecting between Hymovis and Hyalgan depends on the patient’s lifestyle, medical history, and specific needs. 

knee injection for osteoarthritis treatment

Hymovis is well-suited for individuals seeking a convenient treatment option with fewer injections. Its two-injection regimen over a week makes it attractive for busy patients who prefer minimal disruption to their schedules. Additionally, its high-molecular-weight hyaluronic acid may offer extended relief, making it ideal for patients with advanced osteoarthritis or those prioritizing longer-lasting results.

Hyalgan, with its three-to-five weekly injection protocol, caters to individuals who prefer a gradual approach to symptom relief. This regimen may benefit older adults or patients with mild to moderate osteoarthritis who prefer steady improvement over time.

Patient Satisfaction with Hymovis

  • Cou..: “Hymovis works great! No pain, soreness, or side effects. My left knee used to bother me most of the time, but after I had the two shots, all the pain/soreness was gone. The injections were effective for a full year. I am now going to get a second round. Highly recommended!”

Patient Satisfaction with Hyalgan

  • Anonymous: ”Hyalgan injections have worked for me immensely! My first round of 3 lasted a year. I just started my second round as I had a flare-up. Some orthopedic surgeons feel no proof that it works and are convincing the insurance companies not to cover Hyalgan. They are saying it’s a placebo effect. I am living proof that it works for my osteoarthritis!”

Conclusion

Hymovis and Hyalgan are effective viscosupplements that cater to different patient needs for managing knee osteoarthritis. Hymovis’s two-injection protocol provides convenience and potentially longer-lasting relief, making it suitable for patients with busy lifestyles or advanced symptoms. Hyalgan’s multi-injection regimen offers a more gradual approach to symptom management, appealing to individuals who value steady improvement.

Choosing between these treatments depends on factors like medical history, lifestyle, and personal preferences. Consulting with a qualified healthcare provider ensures that the selected treatment aligns with the patient’s specific goals, delivering optimal results for knee joint health.

FAQs

1. What is Hymovis used for?

Hymovis is an injectable hyaluronic acid treatment for knee osteoarthritis. It provides lubrication to the joint, reduces pain, and improves joint movement.

2. How does Hymovis work?

Hymovis contains a unique hyaluronan derivative called HYADD®4, which enhances joint lubrication and helps restore the viscoelastic properties of synovial fluid. This reduces friction in the knee joint, easing pain and improving mobility.

3. How long do the effects of Hymovis last?

The effects of Hymovis typically last up to six months. It provides long-lasting pain relief and improved joint function, which can benefit patients seeking fewer injections over time.

4. What are the possible side effects of Hymovis?

Common side effects of Hymovis may include temporary pain, swelling, or redness at the injection site. Serious side effects are rare, but you should consult your doctor if you experience unusual symptoms after the injection.

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References

Knee joint. Cleveland Clinic. Published May 1, 2024. https://my.clevelandclinic.org/health/body/24777-knee-joint

Galesso D, Finelli I, Paradossi G, Renier D. Viscoelastic properties and elastic recovery of HYADD ® 4 hydrogel compared to crosslinked HA-based commercial viscosupplements. Osteoarthritis and Cartilage. 2012;20:S292. doi:10.1016/j.joca.2012.02.506

Kolarz G, Kotz R, Hochmayer I. Long-term benefits and repeated treatment cycles of intra-articular sodium hyaluronate (Hyalgan) in patients with osteoarthritis of the knee. Seminars in Arthritis and Rheumatism. 2003;32(5):310-319. doi:10.1053/sarh.2002.50013