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Polynucleotides
Polynucleotides Side Effects – What to Expect and How to Manage Them
Jan 27, 2025
Polynucleotide-based treatments are rapidly gaining popularity in aesthetic medicine due to their ability to improve skin texture, boost hydration, and enhance elasticity. A review published in the International Journal of Molecular Sciences highlights their effectiveness in reducing wrinkles and revitalizing the skin, making them a promising solution for non-surgical facial rejuvenation.
While these treatments offer remarkable benefits, it’s important to be aware of potential side effects. As with any injectable procedure, patients may experience mild swelling, redness, or temporary bruising, which typically subside with proper aftercare. Understanding these effects can help individuals feel more confident and prepared before undergoing treatment.
In this article, we will explore the common side effects of polynucleotide treatments and share expert-backed strategies for managing them effectively.
Key Takeaways
- Polynucleotides are naturally occurring molecules composed of nucleotide chains, widely used in medical and aesthetic treatments for their ability to promote tissue repair and regeneration.
- By stimulating cell renewal and enhancing skin structure, these treatments effectively improve elasticity, hydration, and overall skin quality, making them a popular choice for anti-aging and rejuvenation.
- Results can vary depending on factors such as skin type, overall health, and individual response to treatment.
- While polynucleotide treatments are generally well-tolerated, mild side effects like redness or swelling may occur, though these are typically temporary and manageable.
- Following proper aftercare guidelines from a healthcare provider is essential to achieving optimal results and minimizing potential side effects.
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Common Side Effects
Polynucleotide treatments for skin rejuvenation are generally well-tolerated, but like any procedure, they can lead to some mild side effects. Knowing what to expect helps patients feel more prepared and confident during their recovery. Common side effects are usually temporary and manageable, ensuring a smooth experience when adequately addressed. These include:
- Mild Swelling and Redness: This is typical after the procedure and usually resolves within a few hours to a few days.
- Bruising: Some patients may experience bruising at the injection sites, which generally fades within 5 to 7 days.
- Itching or Tenderness: These sensations can occur and are usually manageable with moisturizers or antihistamines.
- Small Lumps or Nodules: Small lumps may form at the injection sites in rare cases. These are typically harmless and can improve with gentle massage or additional care from your doctor.
While these side effects are generally mild and temporary, they help to prepare patients for what to expect after treatment. Understanding these possible effects ensures a smoother experience and helps patients manage their recovery more effectively.
Managing Side Effects
To ensure the best polynucleotides before and after results as well as a good patient experience, practitioners must explain how to manage the temporary side effects of this innovative injectable:

- Apply Cold Compress: Using a cold pack on the treated area for short intervals can help reduce swelling and discomfort within the first 24 hours.
- Avoid Touching or Massaging: Refrain from rubbing or applying pressure to the treated area to prevent irritation and allow optimal absorption of the product.
- Stay Hydrated and Moisturized: Drinking plenty of water and using a gentle, hydrating moisturizer supports skin healing and enhances before-and-after results of polynucleotide treatments.
- Limit Sun Exposure: Protect the skin from direct sunlight and excessive heat for at least a week to prevent inflammation and pigmentation issues.
- Follow Medical Advice: Adhering to post-treatment guidelines from your provider ensures a smooth recovery and minimizes the risk of complications.
Rare Side Effects
Although rare, some side effects of polynucleotide treatments may include infection and allergic reactions. Patients should be aware of these possibilities for prompt management.

- Infection: Signs include redness, warmth, swelling, and pus at the injection site. If these symptoms occur, immediate medical attention is needed.
- Allergic Reactions: Rare reactions may include severe swelling, rash, or difficulty breathing. These require immediate emergency care.
To minimize the risk of infection, it’s essential to use clean techniques during the procedure and follow proper aftercare. Patients should be informed about these rare side effects before treatment so they can recognize symptoms early and seek appropriate help.
Patient Education
Teaching patients about potential side effects helps set expectations and ease concerns. Doctors should explain common reactions like redness or swelling, which usually resolve in a few days. Discussing rare side effects, such as infections or allergic reactions, is also essential.
Clear communication makes patients feel safe. Advising proper aftercare, like using clean techniques and sharing medical history, reduces risks and ensures the best treatment plan for each individual. This helps patients feel more comfortable and informed.
Conclusion
Polynucleotide treatments have revolutionized non-surgical skin rejuvenation, offering a natural approach to improving skin texture, hydration, and elasticity. While these injectables are generally well-tolerated, understanding potential side effects such as mild redness, swelling, and bruising helps ensure a smooth recovery and optimal results.
By following proper aftercare guidelines, patients can minimize discomfort and enhance their before-and-after transformations. Simple steps like applying cold compresses, staying hydrated, and avoiding sun exposure can significantly improve the healing process.
Overall, polynucleotide treatments provide a safe and effective solution for skin regeneration. With realistic expectations and informed aftercare, individuals can achieve long-lasting, youthful skin with minimal downtime. If concerns arise, consulting a qualified practitioner ensures a safe and satisfying experience.
FAQs
1. What are polynucleotides in cosmetics?
Polynucleotides are naturally occurring molecules used in skin treatments for rejuvenation, healing, and hydration.
2. How do polynucleotides benefit the skin?
They help improve skin texture, promote collagen production, and boost hydration, leading to smoother, healthier-looking skin.
3. Do polynucleotides help with wrinkles?
Yes, they can reduce the appearance of fine lines and wrinkles by stimulating collagen production and skin repair.
4. How are polynucleotides applied in cosmetic treatments?
They are typically injected into the skin using microneedling or mesotherapy techniques.
References
Kalra P. Save yourself from getting “plastic skin” after sun exposure! Use these tips. Healthshots. Published August 23, 2022. Accessed January 27, 2025. https://www.healthshots.com/beauty/skin-care/sunscreen-tips-and-how-to-stay-safe-from-sun-exposure/
Yi K, Waranaree Winayanuwattikun, Kim S, et al. Skin boosters: Definitions and varied classifications. Skin research and technology. 2024;30(3). doi:https://doi.org/10.1111/srt.13627