What is Synvisc?
It is a sterile, apyrogenic, viscoelastic solution containing hylans or hyaluronic acid (HA) derivatives for the treatment of knee pain and joint inflammation associated with osteoarthritis (OA). It contains both Hylan A and Hylan B in buffered physiological sodium chloride. Synvisc is only approved FDA for intra-articular injection of the knee. It is being used off-label for other OA-affected joints such as the hips, ankles, and shoulders.
Composition and Characteristics
The active ingredients of Synvisc, Hylan A and B, are made from a type of hyaluronan that is extracted from rooster combs. This naturally occurring substance is also found in large amounts in the human body, particularly in joints, where it acts as a lubricant and shock absorber to help the joints function properly. Hylans are absorbed by the body through the same pathway that degrades hyaluronan. The metabolites produced from Hylan degradation are non-toxic.
Usage of Synvisc
As a temporary r ...
What is Blepharospasm?
Blepharospasm is a progressive neurological condition characterised by abnormal, involuntary contractions and spasms of the eyelids. The term can be applied to any abnormal twitching of blinking of the eyelid, regardless of the underlying causes. Secondary blepharospasm is associated with another condition or syndrome, such as dry eyes, tardive dyskinesia, or Tourette’s syndrome. It must be differentiated from Benign Essential Blepharospasm (BEB), a type of focal cranial dystonia that involves increased contraction of the eyelid muscles leading to involuntary eyelid closure. Despite having normal eyes, patients with BEB may experience visual disturbances or blindness due to the forced closure of the eyelids.
Early Stage Symptoms:
Blepharospasm symptoms may start gradually, beginning with eye irritation or increased blink rate. In the early stages, it is often triggered by precipitating irritants or stressors, including fatigue, corneal or eyelid irrit ...
What is Rosacea?
Rosacea is a chronic facial skin condition characterised by a variety of clinical manifestations, including transient or persistent redness, visible blood vessels on the face, inflamed papules, pustules, and in some cases, red and itchy eyes.
The disorder manifests by way of flare-ups and remissions. Some days are less severe than others. Signs and symptoms come and go, flaring up for a period of weeks to months and fluctuating without worsening for some time. No specific laboratory tests are available for this relapsing condition, and without proper treatment, the redness can become permanent.
While it may occur in anyone, it is more prevalent in middle-aged women with fair skin.
Signs and Symptoms of Rosacea disease
Since there is no definitive test to diagnose rosacea and distinguish it from other cutaneous diseases, experts suggest looking for at least 1 diagnostic sign and 2 major signs. Secondary symptoms may also appear together with 1 or more diagnost ...