What is Radiesse dermal filler?
Radiesse is a collection of aesthetic implants designed and manufactured by Merz Aesthetics. The fillers are made of 70% artificial calcium hydroxylapatite (CaHA) microspheres of only 25 to 45 microns in size suspended in a gel carrier. This aqueous gel carrier solution is composed of carboxymethylcellulose, glycerin, and high purity water. There is a total of 4 different variations of Radiesse fillers.
Radiesse® (+) 0.8mL with Lidocaine
Radiesse® (+) 1.5mL with Lidocaine
All the fillers above share the same gel formulation but different packaging volume. Patients who are hypersensitive to the anaesthetic lidocaine can opt for the ones without lidocaine. The fillers are famed for their durable performance which can last up to a year or more.
What is it used for?
The calcium hydroxylapatite microspheres are calcium and phosphate ions bonded together. This substance functions a ...
What are chronic migraines?
Chronic migraines are a debilitating and painful condition defined as having headaches at a frequency of more than 15 headache days a month over a 3-month period, with the headaches lasting 4 hours a day or longer. Chronic migraine sufferers experience a decrease in productivity because they are often absent more from work, school, and social or leisure activities (as they are usually incapacitated for a lengthy period), significantly impacting their quality of life.
Botox (BTX) injections and migraines
The discovery that Botox (a brand name of botulinum toxin type A) is effective for treating migraines was accidental. Patients receiving BTX treatment for forehead wrinkles started noticing an improvement in their headaches as well. This was explored further in clinical trials which suggested that BTX treatment may be beneficial for sufferers of a particular type of headache, i.e. those afflicted with chronic migraines. Based on these results, as well a ...
Hyaluronic acid dermal fillers are the most common type of filler used, making up 92% of all dermal filler treatments in the United States. Widely used as a biomaterial, hyaluronic acid is valued for its biocompatibility, established safety profile, and excellent clinical performance.
What is cross-linking?
In its natural form, hyaluronic acid is rapidly turned over in the body, as such it has a short half-life of 24–48 hours in tissue. This makes hyaluronic acid, at first glance, a poor choice to be used as a dermal filler. To overcome this limitation however, the hyaluronic acid in most dermal fillers are stabilized by cross-linking the long linear hyaluronic acid chains with other compounds such as 1,4-butanedioldiglycidyl ether (BDDE) and suspended in a physiological or phosphate-buffered solution. This popular compound is used by Restylane, Belotero, and Juvederm.
The product is then processed either as a homogeneous gel or a suspension of particles in gel carriers. ...