What is Synvisc?
It is a sterile, apyrogenic, viscoelastic solution containing hylans or hyaluronic acid (HA) derivatives for the treatment of knee pain and joint inflammation associated with osteoarthritis (OA). It contains both Hylan A and Hylan B in buffered physiological sodium chloride. Synvisc is only approved FDA for intra-articular injection of the knee. It is being used off-label for other OA-affected joints such as the hips, ankles, and shoulders.
Composition and Characteristics
The active ingredients of Synvisc, Hylan A and B, are made from a type of hyaluronan that is extracted from rooster combs. This naturally occurring substance is also found in large amounts in the human body, particularly in joints, where it acts as a lubricant and shock absorber to help the joints function properly. Hylans are absorbed by the body through the same pathway that degrades hyaluronan. The metabolites produced from Hylan degradation are non-toxic.
Usage of Synvisc
As a temporary r ...
What is Blepharospasm?
Blepharospasm is a progressive neurological condition characterised by abnormal, involuntary contractions and spasms of the eyelids. The term can be applied to any abnormal twitching of blinking of the eyelid, regardless of the underlying causes. Secondary blepharospasm is associated with another condition or syndrome, such as dry eyes, tardive dyskinesia, or Tourette’s syndrome. It must be differentiated from Benign Essential Blepharospasm (BEB), a type of focal cranial dystonia that involves increased contraction of the eyelid muscles leading to involuntary eyelid closure. Despite having normal eyes, patients with BEB may experience visual disturbances or blindness due to the forced closure of the eyelids.
Early Stage Symptoms:
Blepharospasm symptoms may start gradually, beginning with eye irritation or increased blink rate. In the early stages, it is often triggered by precipitating irritants or stressors, including fatigue, corneal or eyelid irrit ...
Restylane and Botox are 2 popular injectable anti-ageing injectables. They both provide smoothing of the skin and eliminate deep wrinkles from the complexion. However, the similarities stop there. Each product is made of unique ingredients that work to target specific types of wrinkles.
Restylane Active ingredients
Restylane is a line of highly regarded dermal fillers that deliver a sterile, viscoelastic and bioresorbable hyaluronic-based gel into the dermis. Each formulation works to target varying concerns. Hyaluronic acid occurs naturally in the body but depletes with time and age. The active ingredient in Restylane fillers is extracted from biofermentation of Streptococcus bacteria and further enhanced to create cross-linked Non-Animal Stabilized Hyaluronic Acid (NASHA).
Benefits of Restylane and Botox
The main benefit of hyaluronic acid is its capacity to fill the dermal extracellular matrix with moisture. Its humectant properties allow it to att ...