SHARE THIS ARTICLE
Feb 23, 2018
Hyalase encourages the dispersal and absorption of injectable treatments in bodily tissues. Commonly used to reverse dermal fillers, it comes in the form of a white or off-white powder solution that must be dissolved in water, saline, or another injectable solution before use.
Comprised of hyaluronidase, a natural enzyme, Hyalase works to break down barriers in the bodily tissues. This allows injected substances to be more easily distributed within the injection site.
Hyalase is manufactured by Wockhardt UK Ltd., an established generic pharmaceutical company. Through the conception of high-quality pharmaceuticals and biotechnologies, Wockhardt works to create a healthier world for each individual patient.
Each ampoule of Hyalase contains 1500 international units of hyaluronidase and sodium hydroxide. Hyalase should not be stored above 25°C.
What is it used for?
Hyalase is used to correct unwanted results from dermal fillers.
It is suitable for intramuscular or subcutaneous injection.
How does it work?
Hyalase contains hyaluronidase, an enzyme that is naturally produced in the body. This compound catalyses the breakdown of hyaluronan, a part of the extracellular matrix that supports skin cells, and works to increase the permeability of different tissues.
How to inject Hyalase
Because Hyalase injections are medical procedures, a registered medical practitioner must perform them. This reduces the likelihood of unwanted side effects and ensures patient safety. Please note that the usual dose of Hyalase is 1500IU.
For subcutaneous infusion, 1500IU of Hyalase must be dissolved in 1mL of water or saline prior to use. It may be injected into the skin prior to infusion, or injected into the tubing of the infusion set at the beginning of the procedure.
For subcutaneous or intramuscular injection, 1500IU of Hyalase should be dissolved directly into the solution to be injected.
For extravasation and to treat hematomas, 1500IU of Hyalase should be suspended in 1mL of water or saline.
Hyalase should not be applied directly to the cornea. Additionally, hyaluronidase should not be used to enhance the effects of dopamine or alpha agonist drugs. For more information, see the pamphlet included in the product packaging.
Is this product safe?
While Hyalase injections are usually well tolerated, certain patients should not be injected with hyaluronidase. Those who are allergic or hypersensitive to hyaluronidase should never undergo treatment with this injectable solution. Additionally, caution should be used in patients who are pregnant or breastfeeding.
Please note that Hyalase should never be used for intravenous injections or for anesthetic procedures in cases of unexplained premature labour. Moreover, it should not be used to reduce the swelling of infected or malignant bites or stings.
In case of overdose, patients must seek immediate medical assistance.
Symptoms of overdose include:
- Localized hives, erythema, and swelling;
- Nausea, dizziness, and vomiting;
- And hypotension.
Hyalase has been reported to be physically incompatible with heparin, adrenaline, benzodiazepines, phenytoin, and frusemide.
Although rare, side effects have been known to occur with injection of Hyalase. If these are experienced, patients should seek immediate medical attention. Please note that hyaluronidase has been reported to enhance the occurrence of adverse effects in co-administered drugs.
The following side effects may occur:
- Blurred vision
- Local irritation, bleeding, and bruising
- Eye disorders
What is Hyalase made of?
The main active component of Hyalase is hyaluronidase, an enzyme that is naturally produced in the body. This compound breaks down hyaluronan, which works as a structural and biochemical supporter of the cells. By weakening hyaluronan, hyaluronidase increases the absorbency of bodily tissues. As such, it is often used in tandem with injectable drugs (including anesthetics) to hasten their dispersal into the injection site.
Hyaluronidase is also used to help the body reabsorb excess fluids and blood from the skin tissues. As such, it is excellent for treating extravasation and hematomas.