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What is Mesotherapy Treatment and What are Its Side Effects?

Apr 24, 2018

What is mesotherapy treatment?

The mesotherapy technique, also known as bio-revitalization or bio-rejuvenation, is a non-surgical procedure that rejuvenates the skin via transdermal injection of a combination of various pharmaceuticals. These substances include hyaluronic acid, vitamins and mineral, peptides, amino acids, nucleic acids, and other plant extracts. Advocates of the technique claim that mesotherapy can provide the following benefits:

  • Skin repair;
  • Production of new collagen and other dermal ground substances;
  • Improvement of skin tone and hydration;
  • Localised reduction of fat deposits;
  • Enhanced connective tissue characteristics.


Because of its outstanding hydrating effect on tissues, hyaluronic acid is often used in many mesotherapy “cocktails.” Additional Vitamin C, E, and other antioxidants combat the damaging effects of oxidation.

Mesotherapy Indications

Mesotherapy is often used for skin rejuvenation. Mesotherapy may still be used by doctors off-label to treat various conditions. The combination of ingredients in a mesotherapy injection differs from country to country. The outcome from this procedure varies depending on the product used.

Some fillers are also indicated for mesotherapy injection techniques but are not necessarily mesotherapy treatments. The public’s growing interest for minimally invasive cosmetic procedures will hopefully motivate further evaluation of this method. Depending on the formulation, mesotherapy treatments are indicated for injection into the scalp, face, neck, decollete, and backs of the hands.

Side Effects

The procedure is well tolerated by most patients. Repeat injections are often required to experience the full outcome of the treatment. Generally, these treatments may need to be injected every 1 to 3 months. This is determined by the product used and the patient’s individual needs. Common adverse events may be due to improper injection technique and the injector’s lack of knowledge regarding the treatment procedure. Cases of unqualified injectors administering treatment using impure pharmacological compounds are also common. Most side effects are mild and transient, but serious complications may still occur.

  • Swelling
  • Redness
  • Bruising
  • Itching
  • Localised tenderness or pain
  • Burning sensation
  • Nausea or dizziness
  • Discolouration
  • Infection
  • Abscess formation