DYSPORT® 300u

DYSPORT® 300u (abobotulinumtoxinA) is a botulinum toxin type A product designed for intramuscular injection. It acts as a neuromuscular blocking agent by inhibiting acetylcholine release at the neuromuscular junction, leading to temporary muscle relaxation. Approved by the FDA in 2009, DYSPORT® is widely used for both medical and aesthetic treatments.

Key Features:

• Indications: Treats cervical dystonia, upper limb spasticity in adults, lower limb spasticity in pediatric patients (2+ years), and glabellar lines in adults (<65 years).
• Onset of Action: Effects appear within 1 week after injection.
• Duration: Clinical results last approximately 12 to 16 weeks.
• Dosage Strengths: Available in 300-unit and 500-unit lyophilized vials.
• Mechanism: Blocks nerve signals to muscles, causing temporary relaxation.
• Storage: Must be stored between 2°C and 8°C and used within 24 hours after reconstitution.

DYSPORT® 300u is supplied in a single-use, sterile vial as a white, lyophilized powder that must be reconstituted before injection.

Packaging Details:

• Vial Size: Contains 300 units of abobotulinumtoxinA.
• Formulation: Lyophilized powder for intramuscular injection.
• Reconstitution Requirement: Must be diluted with preservative-free 0.9% sodium chloride solution before use.
• Storage Conditions: Must be kept at 2°C to 8°C (36°F to 46°F) and protected from light.

Ingredients:

• Active Ingredient: AbobotulinumtoxinA (botulinum toxin type A).
• Inactive Ingredients: Human serum albumin (125 mcg) and lactose (2.5 mg).

Allergen Warning: May contain trace amounts of cow’s milk protein.

DYSPORT® 300u is used for multiple therapeutic and aesthetic indications. However, specific contraindications and precautions must be observed.

Indications:

• Cervical Dystonia: Reduces muscle stiffness and abnormal head positions.
• Upper Limb Spasticity (Adults): Relieves excessive muscle tightness in arms.
• Lower Limb Spasticity (Pediatrics, 2+ years): Treats muscle spasticity in children.
• Glabellar Lines: Temporarily improves moderate to severe frown lines between the eyebrows.

Contraindications:

• Allergy to botulinum toxin or formulation components.
• Infection at the injection site.
• Patients with neuromuscular disorders (e.g., myasthenia gravis).

Side Effects:

• Common: Muscle weakness, headache, dry mouth, and injection site reactions.
• Serious (Rare): Breathing difficulties, dysphagia, and generalized muscle weakness.

Proper administration of DYSPORT® 300u is crucial for efficacy and safety. It should only be injected by trained healthcare professionals.

Administration Technique:

• Injection Route: Intramuscular (IM) injection only.
• Reconstitution:
  • 300-unit vial: Reconstitute with 0.6 mL of preservative-free 0.9% sodium chloride solution.
  • Final concentration: 50 units per 0.1 mL.
• Injection Sites: Varies by indication; should be administered into targeted muscles.
• Dosage:
  • Cervical Dystonia: Initial 500-unit dose divided across affected muscles.
  • Glabellar Lines: 50 units total, distributed into 5 equal 10-unit injections.
  • Upper Limb Spasticity: Based on severity; doses range from 500 to 1000 units.
  • Lower Limb Spasticity (Pediatrics): 10-15 units/kg per limb, with a max dose of 1000 units.
• Injection Interval: No more frequent than every 12 weeks.

Storage Guidelines:

• Before Reconstitution: Store vials at 2°C to 8°C (36°F to 46°F).
• After Reconstitution: Must be used within 24 hours and kept refrigerated.
• Do Not Freeze: Freezing compromises potency.
• Light Protection: Store in original packaging to prevent degradation.

DYSPORT® 300u provides effective treatment for neuromuscular conditions and aesthetic concerns. Proper usage, dosage, and storage ensure its safety and efficacy.

Warning! The product is intended solely for professional use in a medical environment and under professional supervision. The product is supplied to medical professionals who specialize in aesthetic medicine (plastic surgery, facial treatments) and work under individual medical licenses as aestheticians or in dedicated clinics. Unprofessional use by individuals without a medical background may lead to severe adverse effects and health harm.