Ellanse is a latex-free, pyrogen-free, completely biodegradable temporary dermal filler created by AQTIS Medical BV. The complete filler range—Ellanse S, M, L, and E—is made of polycaprolactone (PCL) microspheres homogeneously suspended in a gel carrier composed of carboxymethylcellulose (CMC), glycerin, and phosphate buffered saline. Once administered, PCL microspheres stimulate collagen production, resulting in firmer skin and diminished facial creases. Each box comes with 2 prefilled 2mL syringes, 4-27G¾” sterile needles and a patient information leaflet. All the fillers have been packaged in a sterile environment and must be stored in a clean and dry place with the temperature ranging from 15℃ to 25℃.
Ellanse is a natural biostimulator as it helps to boost natural collagen growth in a process known as neocollagenesis.
The skin gets its distinctive elasticity from collagen. This cell is a structural protein found in many parts of the human body—from hard bones to soft yet pliable skin. Collagen fibres provide mechanical strength to skin by forming an interconnected structural framework. Other cells, like hyaluronic acid, cling onto this structural scaffold to perform their individual functions. In younger years, these cells are produced plentifully and function efficiently. But, problems arise when biological ageing and external skin-damaging influences (e.g. smoking, sunlight, pollution, improper diet) put a damper on the quantity and functionality of dermal cells. Hence, wrinkles and creases start emerging on areas where most facial expressions occur, like the forehead and cheeks. If left untreated, patients may end up looking gaunt or older than their age.
Ellanse has been created using PCL microspheres suspended in a gel carrier composed of carboxymethylcellulose (CMC), glycerin, and a phosphate buffered saline. Polycaprolactone is a soft medical polymer generally used in biomedical applications such as sutures, drug delivery systems, and tissue engineering. This polymer is renowned for its non-toxic, biodegradable, and biostimulatory effects. After administering, PCL microspheres increase collagen synthesis and strengthen the skin scaffolding. Hence, skin depressions are seamlessly filled and lifted. Ellanse products are equipped with tuneable longevity and total bioresorbability properties for sustained performance. The treatments are also cost-effective in the long run as the effects are very durable.
Just like any other aesthetic treatments, only approved medical practitioners with vast experience in dermal injections are legally permitted to conduct procedures using Ellanse. Also, it is extremely important to perform the treatment while strictly observing aseptic guidelines. Failure to do so may result in infections and other severe aftereffects. Thoroughly assess patients’ medical information to determine their suitability. Patients should also be informed of of the warnings, precautions, aftercare methods, and possible effects of the chosen filler.
Prior to treatment, disinfect the targeted areas, determine patients’ need for pain relievers and administer suitable anaesthesia if necessary. Assemble the medical device as shown on the patient information leaflet. Once ready, inject the filler slowly into the sub-dermal layer. You may use the tunnelling technique for optimum results. Massage the corrected areas to distribute the filler gel uniformly. Discard any remaining gel and used medical supplies. Refer to the patient information leaflet for detailed instructions for use.
These fillers are different compared to other aesthetic fillers in the market due to their impressive longevity. The viscoelastic gel has tuneable longevity and total bioresorbability properties whereby it can last for an extended period of time, after which it will be completely disintegrated into the neighbouring tissues without a trace. Ellanse products can deliver effects ranging from 1 year to 4 years or more. Nevertheless, the residence time and duration of performance varies on an individual basis.
The Ellanse line of cosmetic fillers is very safe for injection into the human body as it complies with the highest European safety standards for Implantable Medical Devices. The ingredients are toxic-free and tissue-friendly. They do not induce any immunogenic or rejection reactions once administered. Patients do not require any skin allergy test before the procedure since the fillers are completely synthetic and do not contain any pyrogens nor proteins. In fact, these fillers are CE-marked, which further proves their superior quality. That being said, the cases below are advised against using these fillers due to an untested safety profile, including:
It is best that pregnant and breastfeeding patients as well as those younger than 18 years of age avoid this filler due to an unestablished safety level. Refer to the patient information leaflet for a detailed list of contraindications.
Just like any other minimally invasive injection procedure, patients may experience localised inflammatory reactions.
These aftereffects are generally very mild and should resolve within 2 days. Inform your patients to avoid high-impact exercise for at least a day following treatment and to protect the treated areas from excessive sunlight exposure for a week post procedure.
These reactions are very serious and must be treated urgently in the hospital. Refer to the patient information leaflet for a detailed list of side effects.
Ellanse is a range of synthetic aesthetic fillers made of polycaprolactone (PCL) microspheres homogeneously suspended in a gel carrier composed of carboxymethylcellulose (CMC), glycerin and phosphate buffered saline. The temporary gel is free from latex and pyrogen and can be completely resorbed into the surrounding tissues. Ellanse fillers are known as a collagen stimulator as they encourage the skin to manufacture more collagen. Over time, skin is left feeling lifted, tighter and smoother-looking.