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What is the Difference Between Synvisc vs Synvisc One?

Oct 4, 2018

What is Synvisc?

Synvisc is a viscosupplement injectable that is used as treatment for osteoarthritis of the knee. It also goes by the generic name hylan G-F 20 and contains hylan A and hylan B polymers. It helps ease pain and improve mobility in the joints by replacing lost synovial fluid, returning lubrication and cushion to the pained joints. One 2ml dose of Synvisc contains 16mg of hylan polymers. The solution also contains sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate monohydrate, and water.

What is Synvisc One?

Synvisc One is a single-use injectable of hylan G-F 20. It is the same formulation as Synvisc, but it combines three doses of Synvisc. The biggest difference between Synvisc vs Synvisc One is in the doses and treatment method.

Dosage of Synvisc vs Synvisc One

The only difference between Synvisc vs Synvisc One is in the dosage included in one syringe. The recommended dose of Synvisc is one single injection into the joint. This dose should be repeated once a week for three weeks. The recommended dose of Synvisc One is one injection. Because of the difference in dosage between Synvisc vs Synvisc One, the expected time in which a patient will begin to feel relief varies.

Side effects

As Synvisc and Synvisc One are the same formula, the side effects of treatment with Synvisc vs Synvisc One are the same. These mild side effects include:

  • Pain, stiffness, or swelling at the injection site;
  • Muscle pain;
  • Flu-like symptoms;
  • Itching;
  • Headache or dizziness;
  • Numbness or tingly feeling.