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What is Supartz?


Supartz is a viscosupplement formulated to combat the painful symptoms of osteoarthritis in knee joints. The pyrogen-free orthopedic injectable gel is made of purified and viscoelastic hyaluronan (10mg/mL), which replenishes lost synovial fluid in the knee joints to greatly improve joint movements while restoring quality of life to patients living with osteoarthritis. The injectable solution is also composed of a physiologic buffer solution with a pH of 6.8 to 7.8. The manufacturer, Seikagaku Corporation, designed this sterile filler with practicality in mind, and each treatment dosage can be easily personalised to the individual needs of each patient. A box of Supartz comes with 5 prefilled 2.5mL syringes, and an information pamphlet. Store this fragile and sterilized item in a clean and cool (below 25º C) room away from light and out of freezing temperatures. The sterilized item has a shelf life of 42 months and must not be used if the package is damaged or beyond its expiry date.


What is it used for?


Supartz is the perfect non-surgical therapy for patients with knee joint issues who have not found success in managing their osteoarthritis using other methods (e.g. weight loss, exercises, diet modifications, painkillers and/or supplements, or physical therapy). This orthopedic implant helps to preserve remaining joint function and further delay the need for corrective surgery. Once inserted into the damaged joints, the hyaluronan gel covers and protects cartilage and tissue from further friction and damage. Painful grinding is prevented, and normal joint movement is resumed. This product can either be used in combination with other traditional therapies for osteoarthritis, or to possibly replace these methods. 


How does it work?


The knee is a type of hinge that connects 4 bones: the femur (thigh bone), tibia (shin bone), fibula (smaller shin bone), and patella (kneecap). The ends of the femur and the tibia meet at the knee, and are protected by a layer of articular cartilage. This white tissue continuously secretes lubricating synovial fluid to ensure that the bones glide over each other without friction or pain. The fluid also acts as a shock absorber whenever sudden impacts occur. When functioning at optimal health, knee joints provide movement, steadiness, and weight-bearing ability.  

Since the knee joints do so much work, they tend to get exhausted. Usually, the articular cartilage is the first component to be affected, and there is a progressive loss of the cartilage lining as the bones rub together. As a result, there is a steady decline in synovial fluid production. This process is known as osteoarthritis, and painful inflammation occurs as the disease worsens. In some cases, abnormal bone spurs may develop on the exposed bones, making osteoarthritis excruciatingly painful as sufferers also have to deal with swelling, and stiffness. 

In the advanced stages of osteoarthritis, patients might even lose mobility, contributing to a poorer quality of life. Supartz helps ease these incapacitating symptoms by providing lubrication on unhealthy joints. The orthopedic implant contains hyaluronan, which is the same substance found in synovial fluid. In fact, the implant is designed to possess a similar viscoelasticity to synovial fluid. After injections, the joints are well lubricated and the bones can glide against each other with very little friction. Patients can then resume their normal activities effortlessly.


How to inject it?


Prior to procedure, evaluate the patient’s suitability to receive Supartz injections by reviewing their medical history. Information, such as the extent of joint damage, supplements taken (e.g. glucosamine, chondroitin), medications (e.g. acetaminophen), and existing medical issues (e.g. allergies), among other things, can determine the best treatment plan. Just before injecting the product, disinfect the injection site and remove any joint effusion, if present. You can also inject or apply a local anaesthetic to increase patient comfort. Remove the preloaded syringe and attach a sterile hypodermic needle. Inject the gel intra-articularly, directly into the injured joint space. The full 2.5mL should be injected into 1 knee only. If both knees are affected, use 2 different syringes for treatment. Afterwards, carefully dispose of unused gel, used needles, and syringes.

A complete Supartz treatment requires 5 injections on a weekly basis, though some patients may begin to experience results in as few as 3 injections. Throughout procedure, ensure that all the methods are carried out aseptically to minimise risk of infections and inflammations. Only authorised doctors with experience in treating osteoarthritis via viscosupplementation can safely conduct this procedure on patients. Discard any damaged, opened, or expired packages. Please refer to information pamphlet for detailed instructions for use.


How long does it last?


A complete Supartz treatment is administered over the course of 5 injections, each occurring a week apart. Some patients may only need 3 injections for adequate effects. A complete treatment course can provide symptom improvements for up to 6 months.


Is this product safe?


Supartz is a safe orthopedic implant made from sodium hyaluronate that is extracted from rooster combs. Hyaluronan, the main active ingredient, exists naturally as a complex sugar molecule in the human body, which means this injectable solution is highly biocompatible and the risk of undesired reactions is quite low. That being said, certain individuals are contraindicated from using this product:


  • Patients with allergy to avian protein (e.g. egg products, feathers, poultry products);
  • Patients with hypersensitivity to hyaluronic acid products;
  • Patients with inflammation and/or infections on the proposed area of injection.


The safety and effectiveness of Supartz injections in pregnant, nursing, and pediatric patients has not been established. Please refer to the information pamphlet for a complete list of precautions.


Supartz side effects


Your patients may experience some side effects related to the injection, such as:


  • Pain and swelling at treated site;
  • Rash and itching at treated site;
  • Redness at treated site;
  • Warmth at treated site;
  • Nausea and vomiting;
  • Fever;
  • Fainting;
  • Low blood pressure.


To reduce the severity of these reactions, patients must rest their treated joints for a minimum of 2 days following treatment. They must avoid strenuous exercise sessions such as jogging, tennis, weight lifting, and any activities that last for more than an hour. Patients must also seek medical care if any symptoms worsen or persist. Please refer to information pamphlet for a complete list of adverse reactions.


What is it made of?


Supartz is an orthopedic implant of hyaluronan base made from chicken combs. The extracted sodium hyaluronate goes through a purification process that removes harmful proteins and formulates the molecules into a viscoelastic gel. The resulting gel is then reconstituted with a buffer solution with a pH of 6.8 to 7.8. Once injected, exposed bones are protected from further damage and inflammation is decreased.