Aesthetic specialist preparing the syringe for Restylane treatment.
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Last Updated On April 16, 2024

Behind the Scenes: Exploring the Story of Restylane Manufacturer

Mar 29, 2024

The desire to maintain a youthful appearance has a long and rich history. In the 1890s, doctors began fat grafting by transferring tissue from the arms to the face for cosmetic improvement. However, it wasn’t until the 1990s that experts discovered the potential of hyaluronic acid (HA) as a dermal filler.

This breakthrough led to HA fillers becoming the preferred choice for their minimal side effects and high efficacy. Restylane stands as a leading brand in this field, offering a range of hyaluronic acid-based fillers to address various signs of aging. Developed by a Swedish company with a rich history in innovation, Restylane’s journey reflects the ongoing advancements in dermal filler technology.

In this article, we’ll explore the story of Restylane and how it transformed aesthetic medicine.

Key Takeaways

  • Restylane uses non-animal-stabilized hyaluronic acid. The FDA approved it in 2003, and specialists have performed over 65 million treatments worldwide.
  • Galderma focuses on safety and innovation in making Restylane. They follow strict FDA rules and use advanced technology to ensure every product is top quality and works well.
  • Over the past 25 years, Restylane has grown significantly. It has introduced new types of fillers for different needs, like smoothing wrinkles or adding volume to lips. 
  • Doctors trust Restylane because it gives natural-looking results that last. Studies show high satisfaction among patients who use this filler.

Introduction to Restylane and Its Significance in Aesthetic Medicine

Restylane is a renowned dermal filler brand line, produced by Galderma S.A. since 1996, and is composed of non-animal sourced hyaluronic acid (HA). The different types of Restylane filler address the signs of aging by filling in wrinkles and adding volume to the skin, particularly around the mouth and eyes.

The FDA approved Restylane in 2003, recognizing it as the first HA filler for correcting moderate to severe facial wrinkles and folds. Since then, over 65 million treatments worldwide have shown how much people trust Restylane for safe, natural-looking results.

The introduction of Restylane has revolutionized aesthetic medicine by providing a minimally invasive treatment option for facial rejuvenation. Its ability to attract and retain water molecules enhances hydration and volume, leading to a smoother and more youthful appearance. Moreover, Restylane stimulates collagen production, improving skin texture and firmness over time.

Reputation for Safety, Efficacy, and Natural-Looking Results

Restylane has established a reputation for its safety and efficacy, with a track record of almost three decades in the market. In addition to its FDA approval, Restylane has undergone rigorous clinical testing to ensure patient safety.

The treatment results in minimal downtime and has common side effects that are typically mild and temporary. Patients appreciate Restylane’s natural-looking enhancements, making it a trusted choice among practitioners and recipients alike.

The Backstory of the Manufacturer Behind Restylane

Scientists working on Restylane in a laboratory.

Galderma was established in 1981 as a joint venture between L’Oréal and Nestlé, following the invention of the first Cetaphil formulation over 75 years ago. However, the company’s roots go back to 1961, when the Owen Dermatology company started in Dallas, Texas, USA.

Over the years, Galderma has grown to become a leading name in dermatology, with a presence in approximately 100 countries and a commitment to advancing dermatology for every skin story.

Values and Commitment to Innovation

Galderma deeply ingrains innovation in its culture. The company encourages employees to explore new ideas, take calculated risks, and embrace creativity. Galderma’s unique position as a company solely dedicated to dermatology allows it to focus on inventing, developing, and bringing to market innovative solutions that meet the evolving needs of consumers and patients.

Impact on the Field of Dermatology and Medical Aesthetics

Galderma has substantially impacted the field of dermatology and medical aesthetics through its broad, clinically proven range of treatments. The company’s commitment to research and development ensures it remains at the forefront of industry advancements.

The company’s diverse portfolio and educational efforts are highlighted in its contributions to conferences and conventions, showcasing its dedication to pushing the boundaries of injectable aesthetics.

Galderma’s backstory is not just about its origins or products; it’s about a relentless pursuit of excellence and a passion for improving the lives of those with skin health needs. The company’s legacy is evident in its innovative spirit and lasting impact on dermatology and medical aesthetics.

Scientific Research and Development Efforts

Scientists researching Restylane for more advanced formulations.

The success of Restylane is deeply rooted in Galderma’s unwavering commitment to scientific research and development. Here’s a closer look at their efforts:

  • HA Technology: Galderma scientists pioneered using stabilized hyaluronic acid (HA) for aesthetic treatments. Their NASHA™ (Non-Animal Stabilized Hyaluronic Acid) technology creates a smooth, long-lasting gel that integrates seamlessly with the skin.
  • OBT™ for Diverse Needs: Galderma’s Optimal Balance Technology (OBT™) offers a range of HA filler textures with varying lifting capacities. This technology allows practitioners to tailor treatments to address specific concerns and achieve natural-looking results.
  • Clinical Research: Galderma conducts extensive clinical trials to evaluate the safety and efficacy of Restylane products. This ongoing research ensures patients receive treatments backed by robust scientific evidence.

Meticulous Manufacturing Process

Restylane’s manufacturing process is a testament to Galderma’s commitment to excellence. It involves four critical steps: bulk, filling, assembly, and packaging, each underpinned by robust quality control measures. This process ensures the integrity of each syringe and, consequently, the quality of the product delivered to patients.

Quality Control Standards and Regulatory Compliance

Galderma prioritizes patient safety by implementing rigorous quality control measures throughout manufacturing. Every batch of Restylane undergoes thorough testing to meet strict international standards for purity, sterility, and efficacy.

Additionally, Galderma adheres to all regulatory requirements for medical devices in the markets where their products are available. This commitment ensures patients receive safe and effective Restylane treatments that comply with the highest safety benchmarks.

Evolution of Restylane

Female patient receiving Restylane treatment in a clinic.

Restylane’s story is one of continuous innovation, shaping the landscape of aesthetic medicine. Here’s a glimpse into the key milestones, technological advancements, and global impact that have solidified Restylane’s position as a leading brand of dermal fillers.

Key Milestones in the Brand’s History

Restylane has been a significant player in aesthetic medicine for over two decades. Its journey from a groundbreaking idea to a leading brand in cosmetic treatments showcases substantial achievements.

  • Launched in Europe in 1996: This marked Galderma launched Restylane, the first stabilized non-animal hyaluronic acid (HA)dermal filler. It’s the first of its kind, with this step redefining aesthetic treatments and offering a new, safe way to restore youthful skin without animal-derived products. 
  • 2000s: The introduction of Restylane products with varying viscosities (thicknesses) allows for the targeted treatment of different wrinkles and facial folds. In 2003, Restylane gained FDA approval in the United States, setting a high standard for future products in aesthetic medicine.
  • Celebrating 25 years in 2021: Over its long history, aesthetic specialists and experts have administered over 65 million treatments. This milestone reflects trust and satisfaction among users and professionals alike. 
  • Present Day: Restylane continues to be a frontrunner in aesthetics. With a solid commitment to research and development, Restylane has consistently introduced new formulations to meet diverse needs. Each product offers something unique, from smoothing wrinkles to adding volume and enhancing features.

Product Innovations and Advancements in Technology

Restylane has been at the forefront of technological advancements in dermal fillers. The brand introduced the Emervel® line, which combined two unique technologies (OBT and NASHA) for a broad range of gel textures. The XpresHAn Technology™, designed for movement and expression, has allowed Restylane products to integrate seamlessly into the tissue, providing flexible support and natural-looking results.

Global Impact and Widespread Adoption

With over 65 million treatments worldwide, Restylane’s global impact is undeniable. Its success stories have transcended geographical boundaries, reaching individuals from all walks of life and becoming a household name in aesthetic medicine. That’s why when aesthetic specialists wonder where to buy Restylane fillers, they won’t have to look far to get their hands on this revolutionary treatment.

The brand’s commitment to innovation continues to drive the future of aesthetics, ensuring that Restylane remains a trusted choice for practitioners and patients alike.


Exploring the story of Restylane’s maker opens our eyes to a blend of science, innovation, and commitment. This journey illuminates how dedicated research and development lead to products that millions trust for their aesthetic needs.

The team behind Restylane keeps pushing boundaries to offer solutions that make people feel good about themselves. Their legacy is built on quality, safety, and creating personalized aesthetic solutions for those who use them. Indeed, their path in aesthetic medicine shows what happens when passion meets purpose.

About: Trusted by over 2,000+ global clients since 2014, Maylips has become a leading supplier of cosmetic, skincare, and orthopedic products for medical and aesthetic professionals. Maylips offers a wide range of authentic brand-name products at competitive wholesale prices, sourced from around the world. Whether your practice needs dermal fillers, botulinum toxins, mesotherapy, PRP kits, or other solutions, Maylips can provide high-quality products and exceptional customer service. Maylips is more than just a supplier, it is your partner in achieving your medical and aesthetic goals.


1. How does Restylane work?

Restylane injects hyaluronic acid beneath the skin to add volume and smooth wrinkles. The acid attracts water to maintain the added volume and support the skin’s natural structure.

2. Who makes Restylane?

Restylane is manufactured by Galderma, a global company specializing in dermatological treatments and aesthetic medicine.

3. Does Restylane stimulate collagen?

Restylane injections may stimulate the body’s collagen production due to the stretching of the skin cells from the product.

4. Where can Restylane be used?

Restylane can treat facial areas, including the cheeks, lips, nasolabial folds, and around the mouth, for lip enhancement and under eye hollows.

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Kim JE, Sykes JM. Hyaluronic acid fillers: history and overview. Facial Plast Surg. 2011;27(6):523-528. doi:10.1055/s-0031-1298785

The History of Dermal Fillers Aesthetic Advancements Institute (AAI) -. Published February 22, 2018.,the%20arms%20into%20the%20face.