What is The Difference Between Sculptra vs Radiesse?

Soft tissue fillers or dermal fillers are FDA-approved medical devices with proven safety and efficacy in rejuvenating ageing skin. Although hyaluronic acid-based fillers are the most popular injectable is the market, the limited duration of these fillers may leave some patients dissatisfied. Semi-permanent and permanent fillers are gaining a following because of their longer duration of effects, but they are also more inclined to cause adverse events. Aside from the type of material used, the implantation area and diffusion of the medication affect the longevity of the treatment.

Similarities and differences between Sculptra vs Radiesse

Sculptra and Radiesse are semi-permanent soft-tissue fillers that can both provide volume restoration and wrinkle reduction, but they are different in many ways. Both dermal fillers use different types of synthetic materials and they have a different mode of action. Sculptra contains Poly-L-lactic acid microsphere beads that immediately plump up the treated area, but volume correction may take 2 or more months to be fully evident. As Sculptra dissolves, it stimulates the production of new collagen, which provide additional volume.

Radiesse, on the other hand, contains calcium hydroxyapatite, a natural substance commonly found in human bones and teeth. Though it can add volume to the cheeks, chin, and jawline.

Comparison Chart



Contains Poly-L-lactic acid (PLLA)

Contains Calcium hydroxyapatite (CaHA)

No skin testing required

No skin testing required

Non-animal derived

Non-animal derived

May last between 18 to 23 months

May last beyond 12 months

Use for filling nasolabial folds and other deep wrinkles, and enhancing the volume of the cheeks and temples

Used for augmenting cheek bones and jawlines, and filling hollow areas of the cheeks

Immediate results

Results are not immediate       

Requires multiple injections before optimum outcome is seen

Requires at least one injection per year

Costs less than Radiesse

More expensive