Woman receiving Restylane for facial rejuvenation.
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Last Updated On: April 10, 2024

Unraveling the Collagen-Boosting Powers of Restylane

Published on: Mar 27, 2024

Did you know collagen levels steadily diminish as part of the skin’s natural aging process? Once we reach our 20s, the skin produces 1% less collagen each year. Numerous studies have revealed that this decline plays a significant role in forming wrinkles and sagging skin, highlighting collagen’s importance in maintaining the skin’s strength and elasticity. 

Unlike creams and lotions that work superficially, Restylane replenishes lost collagen from within, revitalizing the skin to restore its youthful plumpness and glow. FDA-approved, Restylane aims to restore volume and fullness while smoothing out wrinkles and preventing new ones from forming over time.

In this article, we will explore the science behind Restylane, delve into its different formulations, and uncover this filler’s benefits for those seeking to regain a smoother, more radiant complexion.

Key Takeaways

  • Restylane is a popular dermal filler used for facial rejuvenation and wrinkle reduction.
  • It uses hyaluronic acid, a natural substance in the body that helps keep skin hydrated and bouncy.
  • Restylane has collagen-boosting properties, stimulating collagen production for firmer and more radiant skin.
  • Different formulations of Restylane are available to address specific concerns and areas of the face.
  • Restylane treatment offers minimally invasive procedures, quick recovery, and long-lasting results.

Understanding Restylane and Its Composition

Restylane is a renowned brand of injectable fillers primarily used for cosmetic enhancements. It’s a clear gel formulation of hyaluronic acid, a substance naturally present in the human body, particularly in our connective tissues. 

These fillers aim to reduce the appearance of wrinkles and fine lines, plump up lips, and enhance facial contours. Restylane products come in various formulations, each designed for specific areas of the face and desired outcomes.

Exploring Its Unique Composition with Hyaluronic Acid

The unique composition of Restylane lies in its use of hyaluronic acid (HA), which can hold up to 1,000 times its weight in water. This characteristic helps maintain skin hydration and volume. Restylane’s HA is crosslinked with BDDE, an ingredient that forms a network of HA, providing a durable gel filler. This product is free from animal protein, minimizing allergic reactions and adverse effects.

But how does Restylane work? This filler utilizes the water-retaining properties of HA. Once a specialist injects it into the skin, the HA in Restylane fillers binds to water molecules, increasing moisture. As a result of this effect, the skin becomes smoother, sunken facial features get a needed lift, and creases and folds disappear. Through Restylane, patients restore their skin’s youthful glow.

Collagen-Boosting Capabilities of Restylane

Woman celebrating her glowing and healthy skin.

Collagen is a vital protein that provides structure, firmness, and elasticity to the skin. It is essential in maintaining skin hydration and aiding in wound healing. As the most abundant protein in the human body, collagen levels are crucial for youthful and healthy skin.

Unfortunately, we can’t prevent our collagen levels from dropping since our body naturally produces less and less of this vital protein. This reduction in collagen leads to visible signs of aging, like thinner, drier, less elastic skin and a loss of facial volume. Furthermore, sun exposure, smoking, and genetic factors can contribute to this decline.

Restylane’s Ability to Stimulate Collagen Production

With the recent advancements in aesthetic medicine, some may ask, Does Restylane stimulate collagen? Fortunately, its innovative and powerful formula presents a potential collagen-boosting effect. Though the fillers themselves don’t contain collagen, hyaluronic acid (HA) in Restylane may trigger the body to create more of this protein.

Over the years, studies have suggested that HA may interact with specific cell receptors in the skin. This interaction might send signals to fibroblasts, the cells responsible for collagen production, prompting them to increase collagen synthesis.

It’s necessary to note that the research on Restylane’s ability to stimulate collagen production is ongoing, and the results can vary depending on the individual and the specific type of Restylane used. While some patients may experience a noticeable improvement in skin texture and firmness, it’s not a guaranteed outcome.

Exploring Restylane Formulations

Restylane isn’t a one-size-fits-all solution. The brand offers a range of formulations with unique properties to address various areas of the face and achieve different aesthetic goals. Here’s a closer look at three popular Restylane fillers:

  • Restylane Lyft: Healthcare professionals and specialists use this formulation to add volume and structure to the cheeks or hands. It’s known for creating a more youthful-looking appearance by replenishing lost volume. Clinical studies have shown that 96% of patients agreed that Restylane Lyft improved their appearance after the treatment.
  • Restylane Defyne: This formulation aims to smooth away deep laugh lines, such as nasolabial folds, and can be used to define the shape of the chin. It contains HA and lidocaine, providing a balance of flexibility and support for natural-looking results. It can maintain its effect for up to 12 months.
  • Restylane Refyne: Doctors turn to this formulation when smoothing and softening moderate smile lines and lines around the mouth. It uses XpresHAn Technology™ for flexible refinement of dynamic areas, allowing the filler to move with your expressions. A high patient satisfaction rate has been reported, with 97% satisfied with their results.

Benefits of Restylane Treatment

Female patient receiving Restylane injection in a beauty clinic to achieve facial rejuvenation.

Restylane offers several advantages for those seeking to address signs of aging or enhance facial features. Here’s a breakdown of some key benefits:

  • Minimally Invasive Nature: Restylane treatments are minimally invasive, involving fine-needle injections beneath the skin’s surface. The procedure utilizes hyaluronic acid to add volume and smooth out wrinkles without surgical intervention.
  • Quick Recovery Time: Restylane boasts a quick recovery time, unlike surgeries that require extensive healing downtime. Most patients experience minimal downtime, with some swelling and redness at the injection site that typically subsides within 24 hours. Many individuals can resume almost all normal activities immediately following the procedure.
  • Long-Lasting Results: While not permanent, Restylane delivers long-lasting results. Depending on the specific formulation used and the treated area, the effects can last anywhere from 6 to 18 months. Some patients may even enjoy consistent results for longer before requiring a touch-up appointment.

Addressing Common Concerns and Misconceptions

Restylane is an FDA-approved injectable dermal filler used for mid-to-deep dermal implantation to correct moderate to severe facial wrinkles and folds, such as nasolabial folds. It consists of stabilized, non-animal-sourced hyaluronic acid (HA). Clinical studies have proven Restylane’s safety and effectiveness, and it’s a popular choice in the market of dermal fillers since its approval in the European Union in 1996.

  • Safety Profile: Restylane is generally safe for most patients, with contraindications primarily for those with severe allergies, including allergies to gram-positive bacterial proteins or a history of anaphylaxis. Experts should not use Restylane in areas with active skin sores, pimples, rashes, hives, cysts, or infections. The most common side effects are temporary, including bruising, redness, swelling, pain, and tenderness at the injection site.
  • Effectiveness: Restylane’s effectiveness is evident in its ability to smooth away wrinkles and folds. Depending on the treatment area and whether follow-up treatments are performed 5 or 9 months after the initial treatment, results can last up to 18 months. It has been studied extensively in various applications, including facial wrinkles, folds, and lip augmentation.

Who Can Administer Restylane? 

Qualified and experienced healthcare providers should perform Restylane procedures. This group includes dermatologists, plastic surgeons, cosmetic surgeons, and other physicians who have undergone specific training in facial aesthetics and injection techniques.

  • Training and Certification: Healthcare professionals must have extensive training in facial aging, facial analysis, and using Restylane. They must also know the treatment’s indications and contraindications. These professionals learn various injection techniques, such as needle and cannula injections, and are familiar with complications associated with dermal fillers.
  • Choosing the Right Provider: When considering Restylane treatment, it’s crucial to select a certified provider with a proven track record of successful treatments. Providers should offer a comprehensive consultation to discuss individual needs, potential risks, and expected outcomes. 

Questions to Ask Before Restylane Treatments

Before undergoing Restylane treatments, it’s vital to be well-informed and prepared. Here are some essential questions to consider asking your healthcare provider:

  • What are your qualifications? Ensure the treatment professional is certified and experienced in facial aesthetics and injection techniques.
  • Am I a good candidate for Restylane? Discuss your medical history, allergies, and expectations to determine if Restylane is right.
  • What kind of results can I expect? Understand the realistic outcomes of the treatment and how it aligns with your aesthetic goals.
  • How does Restylane compare to other fillers? Learn about the differences between Restylane and other available fillers to make an informed decision.
  • What can I expect during the treatment? Familiarize yourself with the procedure, duration, and any discomfort you may experience during the injection process.
  • How long will the results last? Discuss the longevity of the results and any necessary follow-up treatments.
  • Can I see before-and-after photos of your previous work? Reviewing the provider’s past results can help set expectations and ensure their expertise.

By asking these questions and openly discussing your concerns, you can gain valuable information and decide whether Restylane treatment is right for you. Feeling comfortable and confident with your chosen provider is essential for a positive experience.

Practical Tips and Recommendations for Restylane Treatment

You should first schedule a consultation with your chosen provider to prepare for your appointment. This initial meeting is crucial for discussing your goals, medical history, and any allergies you may have. Ask thorough questions about the procedure, potential side effects, and expected outcomes.

Be realistic about what Restylane can achieve. Discuss expected results with your doctor, considering your age, skin type, and desired outcome. Restylane offers subtle to moderate improvements, not a dramatic transformation. After the consultation, ensure you show up for your procedure with a clean, makeup-free face. Following these steps will prepare you for a smooth and successful Restylane treatment.

Postprocedure Care and Maintenance of Results

Proper aftercare is essential for optimal results and a speedy recovery after your Restylane treatment. Your doctor may give you post-care instructions, such as using cold compresses or pain relievers to manage pain after the injections. You may also have to avoid excessive sun exposure or intense activities for a while after the treatment.

To maintain and extend the results from Restylane, eat a balanced diet, stay hydrated, and protect your skin from the sun. You can also schedule follow-up appointments with your doctor to monitor progress and discuss the need for touch-up treatments.


Restylane goes beyond just filling wrinkles. It can stimulate collagen production, an essential protein for youthful skin. This versatile filler offers various formulations for targeted concerns, from plumping lips to restoring facial volume.

Plus, the minimally invasive procedure delivers long-lasting results. With proper guidance, Restylane can help you achieve your desired look and enhance your natural beauty.

About: Trusted by over 2,000+ global clients since 2014, Maylips has become a leading supplier of cosmetic, skincare, and orthopedic products for medical and aesthetic professionals. Maylips offers a wide range of authentic brand-name products at competitive wholesale prices, sourced from around the world. Whether your practice needs dermal fillers, botulinum toxins, mesotherapy, PRP kits, or other solutions, Maylips can provide high-quality products and exceptional customer service. Maylips is more than just a supplier, it is your partner in achieving your medical and aesthetic goals.


1. What is Restylane?

Restylane is an FDA-approved brand of dermal fillers made from hyaluronic acid. It aims to smooth wrinkles and plump facial features.

2. What areas can Restylane target?

Restylane can target facial areas, including laugh lines, cheeks, lips, under-eye hollows, and the back of the hands for volume and contour correction.

3. Is Restylane permanent?

Restylane is not a permanent filler; its effects can last between 6 and 18 months, after which the treated area returns to its pre-injection state as the body naturally breaks down the hyaluronic acid.

4. Which Restylane works best for the under eye area?

The best Restylane products for this area are the original Restylane filler and Restylane Eyelight.


Reilly D, Lozano J. Skin collagen through the lifestages: importance for skin health and beauty. Plastic and Aesthetic Research. 2021;8:2. doi:10.20517/2347-9264.2020.153

Stein L. Plumping Up the Volume: Wrinkle Fillers Spur Collagen Production. Scientific American. Published February 20, 2007. Accessed March 21, 2024. https://www.scientificamerican.com/article/plumping-up-the-volume-wr/