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Last Updated On: June 6, 2024

Orthovisc vs. Euflexxa: Differences in Viscosupplementation

Published on: May 5, 2024

In recent years, specialists have developed more therapeutic approaches to treat osteoarthritis in joints like the knee. One of the treatments that have been growing popular is viscosupplementation, which involves injecting hyaluronic acid directly into the affected joint. Orthovisc and Euflexxa stand out among the favored injections for this condition.

These supplements, also called hyaluronan, provide joint lubrication and cushioning. While Orthovisc and Euflexxa help alleviate pain and improve mobility for osteoarthritis patients, understanding each product’s distinct benefits is essential for personalized treatment.

In this article, we delve into the unique contributions of Orthovisc and Euflexxa to viscosupplementation, shedding light on their potential to alleviate knee pain and enhance mobility.

Key Takeaways

  • Orthovisc and Euflexxa are both viscosupplements used to treat knee osteoarthritis by improving joint lubrication, reducing pain, and increasing mobility.
  • Orthovisc is derived from hyaluronic acid sourced from rooster combs and requires three to four injections, while Euflexxa contains highly purified hyaluronic acid and is administered in three injections.
  • Common side effects of both treatments may include pain, swelling, or warmth at the injection site, and doctors choose between Orthovisc and Euflexxa based on factors like the patient’s medical history, severity of osteoarthritis, and treatment responses.

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About Orthovisc

Orthovisc, a hyaluronic acid-based injection, acts like oil for your knees, easing pain and improving movement, particularly for osteoarthritis sufferers. Derived from rooster combs, its thick substance mimics the body’s natural joint fluid, aiding lubrication.


Unlike Euflexxa, Orthovisc offers flexibility in treatment. Doctors administer three to four shots as needed. This tailored approach ensures patients receive optimal relief, reduced discomfort, and improved knee mobility. 

Its unique formulation targets stiff or sore joints, helping restore smooth movement without steroids. Orthovisc stands out for its ability to mimic natural joint fluids, making it a preferred choice for those seeking effective, personalized knee pain relief.

Clinical Efficacy and Evidence of Orthovisc in Viscosupplementation

Studies show that intraarticular hyaluronic acid (IAHA) injections can help restore joint fluid properties, potentially alleviating symptoms of knee osteoarthritis (OA). However, effectiveness varies among IAHA products, so doctors must discuss Orthovisc vs. Synvisc or other similar IAHA treatments before a patient undergoes this treatment.Ā 

Clinical trials in the U.S. have also compared the effectiveness of this injection, which demonstrated that Orthovisc provides significant pain relief to patients who havenā€™t found relief with regular pain medication or exercise, offering a valuable option for managing knee pain caused by osteoarthritis.

About Euflexxa

Euflexxa, a hyaluronic acid-based knee pain treatment, restores smooth joint movement using a clear gel. Its highly purified hyaluronic acid, derived without animal proteins, reduces the risk of allergic reactions. 


Unlike other treatments, Euflexxa’s composition doesn’t rely on avian sources, making it safer for those allergic to bird proteins found in eggs and feathers. With a unique three-injection schedule, Euflexxa ensures gradual improvement over time. Its close match to the body’s hyaluronic acid enhances joint lubrication, reducing pain and improving mobility. 

Patients experience faster and more comfortable recovery, enabling a quicker return to daily activities. Euflexxa offers a balance of safety and effectiveness and is favored by doctors for its reliable results.

Clinical Efficacy and Evidence of Euflexxa in Viscosupplementation

In a study about Intra-articular injections, it was found that Euflexxa is effective in treating knee osteoarthritis. It offers significant pain relief, starting from the first week after injection and improving with further treatments. By the 12th week, a majority of patients experienced substantial pain reduction.

In another study that examined how well Euflexxa works for people with painful knee osteoarthritis, the results showed that Euflexxa significantly improved pain relief and helped patients move better. Itā€™s a promising option for managing knee pain caused by arthritis.

Comparison of Orthovisc and Euflexxa

Discover how Orthovisc and Euflexxa stand apart in their approach to easing joint painā€”each offering unique benefits and ways of treatment. 

  • Injection Techniques: Orthovisc and Euflexxa offer different approaches to treating knee osteoarthritis. Orthovisc requires three to four shots over several weeks, allowing the medicine to spread out during treatment. In contrast, Euflexxa achieves optimal results with just three injections, enabling patients to complete their treatment faster than Orthovisc.
  • Treatment Schedules: Orthovisc and Euflexxa differ in their treatment schedules. Orthovisc typically requires three to four shots, whereas Euflexxa involves a series of three injections. Both aim to ease knee pain caused by osteoarthritis, but their dosing strategies and timelines vary, allowing doctors to tailor treatment plans to each patient’s needs and previous treatment responses.
  • Patient Suitability and Individualized Treatment Considerations: Deciding between Orthovisc and Euflexxa depends on the patient’s specific needs, health, and the severity of their knee osteoarthritis. While some may benefit from three Euflexxa injections, others may require three to four Orthovisc shots. Doctors personalize treatment plans to maximize effectiveness and minimize risks, ensuring optimal pain relief and improved joint function.

Differences in Benefits and Side Effects

Orthovisc and Euflexxa offer unique benefits for easing joint pain, but their side effects may differ. This means doctors can choose the best match for each patient’s needs, making the operation successful and effective.

Comparing Benefits

Euflexxa and Orthovisc are top picks for easing knee pain from osteoarthritis. Both get FDA thumbs up, showing they’re safe and work well. Euflexxa needs three shots to do its best, while Orthovisc might need up to four. This means doctors can choose based on what a patient needs.

People using these treatments find good relief from knee pain. Side effects are rare but could happen with either option. Euflexxa’s unique make-up suits some folks better, helping where other treatments haven’t.

On the flip side, Orthovisc’s flexibility in dosingā€”three or four injectionsā€”lets doctors tailor the treatment more closely to each person’s situation.

Comparing Side Effects

Orthovisc and Euflexxa treat knee osteoarthritis, but their side effects may vary. Patients using Orthovisc sometimes report pain at the injection site, swelling, or heat in the knee. With Euflexxa, similar issues can occur, including pain where the shot was given and, less often, skin rash. 

Neither treatment involves steroids like prednisone or methylprednisolone, which means it is safer for long-term use than other joint pain treatments. Doctors choose between Orthovisc and Euflexxa based on these effects and what works best for each personā€™s body. Every patient reacts differently to medication, so tracking any reactions is key.


Orthovisc and Euflexxa are both valuable viscosupplementation treatments for managing osteoarthritis-related joint pain. Their unique compositions, injection techniques, and treatment schedules allow individualized treatment considerations, catering to patients’ specific needs. 

Healthcare providers should carefully evaluate the differences between Orthovisc and Euflexxa to optimize treatment outcomes and improve the quality of care for patients undergoing viscosupplementation therapy.


1. What is Orthovisc, and how does it differ from Euflexxa?

Orthovisc and Euflexxa are both treatments for knee osteoarthritis, but they have different formulations and dosing schedules. Orthovisc is made from hyaluronic acid derived from rooster combs and requires three to four injections. Euflexxa contains highly purified hyaluronic acid and is administered in three injections.

2. What are the potential side effects of Orthovisc and Euflexxa?

Common side effects of both treatments may include pain, swelling, or warmth at the injection site. Allergic reactions are rare but possible.

3. How do doctors decide between Orthovisc and Euflexxa?

The choice depends on factors like the patient’s medical history, severity of osteoarthritis, and treatment responses. Your doctor will recommend the most suitable option for your needs.

4. How do Orthovisc and Euflexxa help with knee pain?

Orthovisc and Euflexxa are both injections used to treat knee osteoarthritis. They improve joint lubrication, reduce pain, and increase mobility.

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Using Orthovisc in Viscosupplementation. Verywell Health.

Webner D, Huang Y, Hummer CD. Intraarticular Hyaluronic Acid Preparations for Knee Osteoarthritis: Are Some Better Than Others? CARTILAGE. Published online May 28, 2021:194760352110173. doi: