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Nucleofill
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Last Updated On December 6, 2024

Nucleofill vs Profhilo – A Thorough Comparison

Dec 3, 2024

The global aesthetics injectables market is experiencing remarkable growth, with projections from McKinsey & Company estimating an annual increase of 12 to 14 percent over the next five years. This surge is fueled by factors like greater accessibility to services, evolving attitudes toward wellness and beauty, and the constant innovation of new products and procedures.

Among these innovations are Nucleofill and Profhilo, two cutting-edge injectable treatments that have gained significant attention in the cosmetic industry. Both are designed to rejuvenate and hydrate the skin, meeting the rising demand for non-invasive aesthetic solutions while offering unique benefits and treatment experiences.

In this article, we’ll thoroughly compare Nucleofill vs Profhilo, examining their benefits, treatment processes, and what patients can expect from these advanced skin treatments.

Key Takeaways

  • Nucleofill emphasizes skin repair and elasticity, while Profhilo excels in deep hydration and lifting.
  • Nucleofill uses polynucleotides to stimulate collagen and repair tissues, while Profhilo relies on high-concentration hyaluronic acid to hydrate and firm the skin.
  • Nucleofill is best for the face and neck, addressing laxity and texture, while Profhilo treats larger areas, including the hands and decolletage, for hydration and radiance.
  • Both treatments deliver natural-looking improvements in skin quality, as seen in Nucleofill before and after comparisons and Profhilo’s lifting effects.
  • Nucleofill requires precise dermal injections, while Profhilo uses the BAP (Bio Aesthetics Point) technique to distribute the product evenly.
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Introduction to Nucleofill and Profhilo

Nucleofill and Profhilo have emerged as two of the most sought-after treatments in the world of non-invasive aesthetics. Both are designed to rejuvenate and enhance skin quality, catering to individuals looking for advanced solutions to address signs of aging and skin concerns.

top view of patient injection

While Nucleofill is known for improving skin elasticity and promoting a youthful appearance, Profhilo is celebrated for its hydrating and lifting effects. Each treatment offers unique benefits, making them versatile options for a variety of aesthetic goals. Choosing between the two often depends on personal preferences and desired outcomes.

Formulation and Mechanism of Action

Nucleofill and Profhilo are advanced injectable treatments that improve skin health and aesthetics, each with a distinct formulation and mechanism of action.

woman with healthy, rejuvenated skin

Nucleofill is formulated with natural polynucleotides, which stimulate the skin’s repair processes. This treatment enhances elasticity and provides deep hydration without pulling excessive water into the skin. It restores moisture, reduces dryness, and improves the skin’s stretchiness, making it particularly effective for areas like the face and neck. 

As for Profhilo, it is composed of high-concentration hyaluronic acid, a substance renowned for its hydrating and skin-tightening properties. As a skin booster, Profhilo deeply hydrates by drawing water into the skin, supporting natural hydration and improving firmness and radiance. This mechanism helps lift and rejuvenate the skin, leaving it with a plumper, more youthful appearance.

Treatment Areas and Injection Techniques

Both Nucleofill and Profhilo are versatile injectable treatments that can improve skin quality in specific areas. Nucleofill treatments typically target the following areas:

  • Cheeks
  • Nasolabial folds
  • Jawline
  • Under eyes
  • Forehead

Injection techniques vary based on the area, with methods such as mesotherapy for superficial bio-restructuring and linear retrograde technique with a cannula for deep tissue bio-restructuring.

For Profhilo, it is ideal to treat the following areas:

  • Face
  • Neck
  • Hands
  • Decolletage
  • Arms

The Bio Aesthetic Points (BAP) technique is commonly employed when administering Profhilo, involving injections at five key points on each side of the face to ensure even distribution and optimal results.

Patient Outcomes and Comparison

Both fillers offer impressive results as seen in Profhilo and Nucleofill before and after images, but they take different approaches. Nucleofill works from the inside out, improving skin elasticity and reducing fine lines by boosting hydration and repair.

result of the cosmetic injection

Image Courtesy of The Luxe Clinic

The patient underwent Nucleofill treatment to address under-eye puffiness and fine lines. After two sessions, the patient experienced smoother, firmer skin with reduced puffiness and a more youthful appearance.

On the other hand, Profhilo, made of hyaluronic acid, deeply hydrates and revitalizes skin by drawing in moisture, resulting in firmer, glowing skin. While Nucleofill repairs and strengthens, Profhilo enhances texture and tone, leaving patients with refreshed, radiant skin. Both treatments offer transformative, long-lasting effects.

comparison of Profhilo before and after

Image Courtesy of Forever Beautiful Aesthetics

The patient underwent Profhilo treatment to combat sagging skin and visible signs of aging. The result was a noticeable improvement in skin firmness, hydration, and rejuvenation.

Conclusion

Nucleofill and Profhilo offer innovative approaches to non-surgical skin rejuvenation, catering to different skin needs and aesthetic goals. Nucleofill focuses on natural repair and elasticity, making it ideal for those seeking gradual, regenerative improvements. Profhilo, with its superior hydrating and lifting properties, is perfect for individuals looking for immediate radiance and firmness.

Choosing between these treatments depends on individual preferences, skin concerns, and desired outcomes. With proper application by a trained professional, both can deliver transformative, natural-looking results.

FAQs

1. What is the main difference between Nucleofill and Profhilo?

Nucleofill targets skin repair and elasticity using polynucleotides, while Profhilo hydrates and lifts the skin with high-concentration hyaluronic acid.

2. How many sessions does each treatment require?

Nucleofill and Profhilo typically require 2–3 sessions spaced a few weeks apart for optimal results.

3. Which areas can Nucleofill and Profhilo treat?

Nucleofill is ideal for the face and neck, while Profhilo works well on the face, neck, hands, and decolletage.

4. How long do the results of these treatments last?

Results for both treatments typically last 6–12 months, with maintenance sessions recommended for prolonged benefits.

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References

Leclerc O, Peters N, Scaglione A, Waring J. From extreme to mainstream: The future of aesthetics injectables. McKinsey & Company. Published December 20, 2021. https://www.mckinsey.com/industries/life-sciences/our-insights/from-extreme-to-mainstream-the-future-of-aesthetics-injectables

Everett JS, Sommers MS. Skin Viscoelasticity. Biological Research For Nursing. 2012;15(3):338-346. doi:https://doi.org/10.1177/10998004114341511