Follistatin 344 (95%) 1mg

Description

Strength: 1mg
CAS: N/A
Chemical Formula: N/A
Molecular weight: 3780 g/mol
Synonyms: FST, Activin-Binding Protein
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

Follistatin 344 peptide is a recombinant form of the follistatin protein, typically representing the mature isoform of approximately 315 amino acids, derived from a 344–amino acid precursor following cleavage of a 29–amino acid signal peptide. It has been extensively studied in laboratory settings for its role in growth factor regulation and muscle-related signaling pathways.

Functionally, follistatin 344 acts as a high-affinity binding protein for select members of the transforming growth factor-beta (TGF-β) superfamily, most notably myostatin and activin—both recognized regulators of cellular growth, differentiation, and tissue remodeling.

Follistatin 344 (1mg) is supplied as a ≥95% pure lyophilized powder in sterile vials, manufactured to research-grade standards. It is intended exclusively for laboratory research use and is commonly employed in preclinical models focused on muscle biology, regenerative signaling, and cellular regulation. Laboratories that buy follistatin peptide typically use this format for controlled in vitro and animal studies.

• ≥95% purity verified for consistency and reproducibility in research
• Lyophilized formulation designed to preserve structural integrity
• Supplied in sealed sterile vials for controlled laboratory handling
• Suitable for in vitro studies and animal research models
• Supports investigations into muscle growth regulation and TGF-β signaling pathways
• Stable under recommended frozen storage conditions

Follistatin 344 is primarily studied for its inhibitory interaction with myostatin, a key negative regulator of skeletal muscle growth. By binding myostatin and activin, the peptide prevents receptor activation, enabling researchers to examine downstream effects on muscle cell proliferation, differentiation, and repair without direct receptor stimulation.

Common Research Applications

• Myostatin & Activin Suppression: Investigated to understand how blocking growth-inhibitory factors alters muscle-related signaling cascades
• Muscle Hypertrophy Models: Applied in preclinical studies assessing muscle fiber size, regenerative capacity, and protein synthesis markers
• Cellular Growth Regulation: Used to explore TGF-β–mediated pathways involved in tissue development and remodeling

Additional investigations examine follistatin 344’s broader role in anabolic–catabolic balance within controlled experimental systems, particularly in musculoskeletal and regenerative biology research.

All dosing information for the follistatin 344 peptide originates from experimental and preclinical research, with protocols varying by model and study objective.

• Animal Studies: Typically evaluate weight-adjusted microgram dosing to assess systemic signaling effects
• In Vitro Studies: Use concentration-specific exposure to measure cellular responses and gene-expression changes

Reported Research Observations

• Reduced myostatin signaling activity
• Increased markers associated with muscle cell growth and differentiation
• Altered expression of proteins involved in tissue repair and regeneration

There are no standardized dosing guidelines and no approved clinical data regarding human safety or efficacy. All findings should be interpreted strictly within controlled laboratory research frameworks.

Proper storage and handling are essential for preserving peptide integrity and ensuring reliable experimental outcomes.

• Unreconstituted: Store lyophilized vials at –20°C, protected from light and moisture
• After Reconstitution: Store at 2–8°C and use within a protocol-defined timeframe
• Avoid Freeze–Thaw Cycles: Repeated temperature changes may compromise stability
• Aseptic Handling: Use appropriate laboratory PPE and sterile technique at all times
• Disposal: Follow institutional and local regulations for laboratory research materials

This product is supplied strictly for laboratory research use only. Institutions that order follistatin peptide must ensure handling and use remain within approved experimental settings.

References

https://pubmed.ncbi.nlm.nih.gov/21689628/

https://www.sciencedirect.com/science/article/pii/S0022356524262182

https://pmc.ncbi.nlm.nih.gov/articles/PMC11122067/

https://www.researchgate.net/publication/23998820_Inhibition_of_myostatin_with_emphasis_on_follistatin_as_a_therapy_for_muscle_disease

Compliance Notice

This product is intended for laboratory research use only. It is not approved for human or veterinary use.