Gonadorelin 10mg

Description

Strength: 10mg
CAS: 33515-09-02
Chemical Formula: C₅₅H₇₅N₁₇O₁₃
Molecular weight: 1182.3 g/mol
Peptide Sequence: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly
Synonyms: GnRH, LHRH, LH-RH, Gonadotropin-Releasing Hormone, Luteinizing Hormone-Releasing Hormone, Gonadoliberin, Factrel
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

Gonadorelin peptide is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH), a central regulator of the hypothalamic–pituitary–gonadal (HPG) axis. In laboratory research, it is used to study receptor-mediated endocrine signaling and the dynamics of hormone regulation. With a molecular weight of approximately 1,182.3 Da, Gonadorelin serves as a well-defined model peptide for investigating pituitary signaling pathways.

This compound is supplied as a lyophilized (freeze-dried) powder, supporting stability, precise handling, and reproducibility in controlled research environments. Laboratories that buy Gonadorelin peptide do so exclusively for regulated, non-clinical research use.

• High Structural Fidelity: Synthetic sequence identical to native GnRH for accurate receptor interaction studies
• Lyophilized Stability: Freeze-dried format supports long-term storage and experimental consistency
• Endocrine Research Utility: Used to investigate pituitary hormone regulation and HPG axis signaling
• Receptor Specificity: Selective agonist of pituitary GnRH receptors, suitable for pharmacology studies
• Controlled Preparation: Enables precise reconstitution and dosing for reproducible experimental protocols

Gonadorelin functions as a GnRH receptor agonist, binding to receptors on anterior pituitary gonadotrophs. This interaction activates Gq/11-linked signaling pathways, increases intracellular calcium mobilization, and stimulates protein kinase C–mediated cascades.

Common research applications include:

• GnRH Receptor Pharmacology: Characterizing receptor binding, signaling efficiency, and ligand kinetics
• Gonadotropin Secretion Models: Examining regulated LH and FSH synthesis and release
• HPG Axis Feedback Studies: Investigating pulsatile signaling and endocrine feedback mechanisms
• Comparative Endocrinology: Evaluating receptor responses across experimental species

These applications support mechanistic endocrine research rather than generalized biological claims.

In research settings, Gonadorelin dosing strategies are designed to replicate endogenous GnRH signaling patterns and support controlled investigation of endocrine pathways.

• Dosing Protocols: Experimental dosing varies by study design and model, commonly using microgram-range preparations to simulate physiological, pulsatile receptor stimulation
• Observed Effects: Preclinical and in vitro studies consistently report GnRH receptor engagement, calcium signaling activation, and regulated LH and FSH secretion

These outcomes reflect controlled experimental observations and should not be interpreted as clinical effects.

Proper storage and handling are essential to preserve peptide integrity and ensure reproducibility when laboratories order Gonadorelin peptide for research use.

• Storage (Lyophilized): Store at −20 °C for long-term stability; short-term storage at 2–8 °C is acceptable when necessary
• Post-Reconstitution: Store reconstituted solutions at 2–8 °C and use within protocol-defined stability windows
• Handling: Use sterile equipment and aseptic technique; minimize exposure to light, moisture, and repeated freeze–thaw cycles
• Reconstitution: Gently swirl rather than shake to reduce mechanical stress and limit peptide degradation

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC3834291/

https://pmc.ncbi.nlm.nih.gov/articles/PMC5662886/

https://pubmed.ncbi.nlm.nih.gov/18708085/

https://pmc.ncbi.nlm.nih.gov/articles/PMC3947649/

https://pmc.ncbi.nlm.nih.gov/articles/PMC4813373/

https://www.ncbi.nlm.nih.gov/books/NBK558992/

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.