Gonadorelin 5mg

Description

Strength: 5mg
CAS: 33515-09-02
Chemical Formula: C₅₅H₇₅N₁₇O₁₃
Molecular weight: 1182.3 g/mol
Peptide Sequence: Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly
Synonyms: GnRH, LHRH, LH-RH, Gonadotropin-Releasing Hormone, Luteinizing Hormone-Releasing Hormone, Gonadoliberin, Factrel
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

Gonadorelin peptide is a synthetic decapeptide identical to endogenous gonadotropin-releasing hormone (GnRH), designed to replicate its native amino acid sequence and receptor-mediated signaling behavior. Because GnRH plays a central role in coordinating hypothalamic–pituitary communication, Gonadorelin is widely used in laboratory research focused on endocrine regulation, receptor responsiveness, and hormonal signaling dynamics.

The 5 mg vial format is commonly selected for studies requiring precise control over dosing schedules, particularly protocols evaluating pulsatile versus continuous GnRH exposure. Supplied as a lyophilized powder, Gonadorelin supports consistent preparation, extended stability, and accurate concentration control. Laboratories that buy Gonadorelin peptide typically use it exclusively in regulated research environments to ensure reproducible experimental outcomes.

• High Structural Accuracy: Identical amino acid sequence to endogenous human GnRH, supporting reliable receptor-binding and signaling studies
• Lyophilized Stability: Freeze-dried format enhances shelf life and preserves peptide integrity during storage
• Endocrine Research Utility: Used in studies examining luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion and HPG axis regulation
• Pulsatile Signaling Model: Suitable for experimental protocols designed to replicate physiological GnRH release patterns
• Laboratory-Friendly Handling: Easily reconstituted with standard laboratory solvents for precise experimental dosing

Gonadorelin acts as a selective GnRH receptor agonist on gonadotroph cells of the anterior pituitary. Upon receptor binding, it activates G protein–coupled signaling pathways, leading to intracellular calcium mobilization and regulated secretion of LH and FSH. For this reason, researchers frequently order Gonadorelin peptide for controlled investigations of endocrine signaling mechanisms.

Common research applications include:

• Pituitary Hormone Release: Controlled stimulation of LH and FSH synthesis and secretion
• HPG Axis Regulation: Investigation of endocrine feedback and hypothalamic–pituitary signaling loops
• Fertility-Related Models: Evaluation of gonadal function in reproductive and suppression-based study designs
• Diagnostic Research: Assessment of pituitary responsiveness in experimental endocrine models

These applications support mechanistic research and do not represent therapeutic or clinical use.

• Dosing Protocols: Research dosing is protocol-dependent and commonly employs microgram-range, pulsatile administration to mimic endogenous GnRH secretion patterns
• Observed Effects: Experimental studies demonstrate GnRH receptor activation, downstream calcium signaling, and regulated LH/FSH release
• Exposure Patterns: Continuous exposure models show receptor desensitization, underscoring the importance of dosing pattern selection

All observations are derived from preclinical or in vitro research and are reported for scientific context only.

Proper storage and handling are essential to preserve gonadorelin stability and ensure reproducible research outcomes.

• Storage (Lyophilized): Store at –20°C for long-term stability; 2–8°C is acceptable for short-term storage
• Post-Reconstitution: Store reconstituted solutions at 2–8°C and use within recommended stability windows
• Handling: Use sterile equipment and aseptic technique; protect from moisture, heat, and light
• Reconstitution: Allow vials to equilibrate to room temperature before opening; gently swirl—do not shake
• Freeze–Thaw: Avoid freezing reconstituted solutions, as repeated temperature cycling may compromise peptide integrity

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC3834291/

https://pmc.ncbi.nlm.nih.gov/articles/PMC5662886/

https://pubmed.ncbi.nlm.nih.gov/18708085/

https://pmc.ncbi.nlm.nih.gov/articles/PMC3947649/

https://pmc.ncbi.nlm.nih.gov/articles/PMC4813373/

https://www.ncbi.nlm.nih.gov/books/NBK558992/

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.