MT-1

Description

Strength: 10mg
CAS: 75921-69-6
Chemical Formula: C₇₈H₁₁₁N₂₁O₁₉
Molecular weight: 1646.874 g/mol
Peptide Sequence: Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val
Synonyms: MT-1
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

MT-1 is a synthetic version of α-melanocyte-stimulating hormone (α-MSH), a naturally occurring peptide that regulates skin pigmentation. It has a molecular weight of approximately 1646.85 Da and is provided as a high-purity, lyophilized powder in a 10 mg vial. MT-1 is used primarily in research to study its effects on skin cells, melanin production, and the body’s response to stress.

Research focuses on MT-1 peptide for understanding pigmentation regulation, UV protection, and its role in cellular stress management.

• High Purity: ≥98% purity for reliable research results.
• Lyophilized Format: Supplied in sealed vials to preserve stability during transport and storage.
• Melanin Production: Studied for its role in pigmentation and UV protection.
• Versatile Research Tool: Suitable for in vitro and cell-based studies, including research on oxidative stress.

MT-1 is a melanocortin receptor agonist that activates several melanocortin receptors (MC1R, MC3R, MC4R, and MC5R). In skin cells, it mainly works through MC1R, stimulating melanin production and boosting protection against oxidative stress. Researchers use MT-1 to study pigmentation, UV protection, and cellular defense mechanisms.

Key research areas include:

• Pigmentation Studies: Examining how MT-1 affects melanin production and skin pigmentation.
• Oxidative Stress: Investigating how MT-1 helps skin cells cope with UV-induced stress.
• Receptor Signaling: Studying how MT-1 interacts with melanocortin receptors to regulate various biological processes.

In preclinical studies, dosing varies by species and route.

• Rodent studies typically use 1.0–25.0 mg/kg/day administered subcutaneously.
• Human research studies have employed 0.08–0.16 mg/kg/day or fixed doses of 1–3 mg/day for pigmentation research.
• Cell culture studies use nanomolar to micromolar concentrations.

All dosing is experiment-specific and depends on the research objective, route of administration, and measurement endpoints.

More observed effects include:

• Increased melanin production in skin cells.
• Altered cellular signaling, especially related to oxidative stress and UV protection.
• Improved resistance to UV damage and enhanced stress responses in skin cells.

These observations are based on research in controlled laboratory settings and animal models, and not intended for clinical use.

To maintain MT-1 peptide’s stability, store it lyophilized at –20°C or below, away from light and moisture. After reconstitution, store the solution at 2–8°C and use promptly.

Handling MT-1 peptide for research requires:

• Using aseptic techniques and wearing PPE (gloves, lab coat, and eye protection).
• Avoiding multiple freeze-thaw cycles to preserve peptide activity.
• Disposing of unused material as per local safety guidelines.

References

https://pubmed.ncbi.nlm.nih.gov/1325670/

https://pubmed.ncbi.nlm.nih.gov/15262693/

https://pubmed.ncbi.nlm.nih.gov/10816645/

https://pubmed.ncbi.nlm.nih.gov/10841026/

https://pmc.ncbi.nlm.nih.gov/articles/PMC11664455/

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.