N-acetyl Epithalon Amidate 50mg

Description

Strength: 50mg
CAS: 307297-39-8
Chemical Formula: C₁₄H₂₂N₄O₉
Molecular weight: 446.45 g/mol
Peptide Sequence: Acetyl-Epithalon-Amidate, Ac-AEDG-NH₂, Epitalon modified
Synonyms: Gonadotropin-releasing hormone, Luteinizing hormone-releasing hormone, GnRH
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

N-acetyl Epithalon Amidate is a modified tetrapeptide derived from Epithalon (Ala–Glu–Asp–Gly; AEDG), designed to enhance molecular stability and resistance to enzymatic degradation in laboratory research settings.

N-terminal acetylation and C-terminal amidation are commonly employed in peptide chemistry to reduce susceptibility to exopeptidase-mediated degradation and to modify physicochemical properties such as charge distribution, which can influence stability and persistence in experimental biological matrices.

This N-acetyl Epithalon Amidate (50mg) is supplied as a high-purity, lyophilized powder in sterile vials. Researchers may buy N-Acetyl Epithalon peptide strictly for controlled laboratory studies that require consistent handling and an extended exposure protocol.

• Amino Acid Sequence: Ala–Glu–Asp–Gly (AEDG)
• Molecular Weight:45 g/mol
• Molecular Formula: C₁₄H₂₂N₄O₉
• CAS Number: 307297-39-8
• PubChem CID: 219042
• Synonyms: Epitalon, Epithalone, Epithalamin, Epithalamine

• Stabilized peptide design: N-terminal acetylation and C-terminal amidation intended to improve resistance to enzymatic degradation
• High purity and consistency: Lyophilized powder with verified sequence identity for research use
• Research-optimized format: Supplied in sterile vials for controlled reconstitution
• Primary research areas: Investigated in telomerase-related endpoints, cellular aging models, epigenetic signaling, and oxidative stress response pathways
• Preclinical applications: Studied in cell culture systems and animal models, including:
  • Telomerase activation and telomere length studies
  • Circadian rhythm and pineal-associated research
  • Cellular differentiation and neurogenesis models
  • Oxidative stress and redox biochemistry assays
  • Gene-expression profiling and epigenetic regulation
  • Systems-level animal investigations
• Storage integrity: Store lyophilized material under cold, dry, light-protected conditions; reconstituted solutions should be refrigerated and used within protocol-defined timeframes
• Regulatory notice: For laboratory research use only
• Ordering information: Institutions that order N-Acetyl Epithalon peptide must restrict use to qualified research environments

The parent tetrapeptide Epithalon (Ala–Glu–Asp–Gly) has been studied for its potential to influence telomerase-associated activity and gene-expression patterns linked to cellular aging and circadian biology. The N-acetyl and C-amide modifications in N-acetyl Epithalon Amidate are intended to enhance peptide stability in experimental settings.

Research models examine interactions with pineal-associated signaling, chromatin-related pathways (including clock genes such as PER1), and mechanisms involved in cellular lifespan regulation. These investigations remain limited to in vitro and animal research systems and do not constitute therapeutic claims.

In the preclinical literature, Epithalon and its derivatives have been evaluated using microgram-scale dosing protocols that vary by model, route of administration, and research objective. No standardized dosing methodology exists across studies.

Reported research observations include:

• Changes in telomerase-associated markers
• Modulation of circadian rhythm–related gene expression
• Shifts in cellular lifespan indicators
• Alterations in oxidative stress markers and lipid-peroxidation-associated products

All findings are derived exclusively from non-human experimental models. There is no approved dosage or established safety profile for human use.

N-acetyl Epithalon Amidate (50mg) — Storage, Safety & References

Lyophilized N-acetyl Epithalon Amidate should be stored at cold temperatures, protected from light and moisture, and kept sealed when not in use. After reconstitution, refrigerate at 2–8°C and use within a short, protocol-defined timeframe.

Avoid repeated freeze–thaw cycles, as they may compromise peptide integrity. Always use aseptic technique and standard laboratory safety procedures during handling.

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC12411320/

https://pmc.ncbi.nlm.nih.gov/articles/PMC11943447/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7037223/

https://pmc.ncbi.nlm.nih.gov/articles/PMC22314/

https://pmc.ncbi.nlm.nih.gov/articles/PMC9037278/

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.