NAD+ 1000mg

NAD+ (Nicotinamide Adenine Dinucleotide) is an essential pyridine nucleotide coenzyme involved in cellular redox reactions, mitochondrial energy production, and enzymatic signaling pathways. NAD+ cycles between its oxidized (NAD+) and reduced (NADH) states, enabling electron transfer during oxidative phosphorylation and glycolytic energy transfer, and supporting processes linked to DNA repair, transcriptional regulation, and cellular homeostasis.

This NAD+ (1000mg) formulation is supplied as a high-purity, lyophilized powder in sterile, sealed vials for laboratory research use only. Researchers investigating metabolic function, mitochondrial biology, cellular stress responses, and aging-associated pathways may choose to buy NAD+ for controlled experimental applications.

• Molecular Formula: C₂₁H₂₇N₇O₁₄P₂
• Molecular Weight: 663.43 g/mol
• CAS Number: 53-84-9
• PubChem CID: 925

NAD+ is one of the most extensively studied metabolic cofactors in cellular and mitochondrial biology. While widely researched, it is not approved for clinical administration in this format and must be used strictly in laboratory settings.

• Essential Cellular Coenzyme: Central to redox biochemistry, ATP production, and metabolic flux
• High Purity & Stability: Pharmaceutical-grade lyophilized material with verified molecular integrity
• Research-Optimized Format: Supplied in sterile vials requiring laboratory-grade reconstitution
• Primary Research Areas:
  • Mitochondrial function and oxidative metabolism
  • Cellular energy regulation and redox biochemistry
  • Sirtuin, PARP, and dehydrogenase activity measurements
  • Transcriptomic and metabolomic profiling studies
  • Cellular stress and aging-associated model systems
  • Neurodegeneration-oriented research models
  • Inflammation-related measurements and cytokine signaling
  • Extracellular signaling experiments and nucleotide receptor responses
• Broad Model Use: Investigated across in vitro systems and animal models involving metabolic, neural, and muscular tissues
• Storage Integrity: Store at 2–8 °C; reconstituted solutions should be refrigerated and used promptly
• Regulatory Notice: Intended exclusively for laboratory research. Researchers should only order NAD+ from authorized laboratory suppliers

NAD+ functions as a critical coenzyme for multiple classes of enzymes, including dehydrogenases (e.g., lactate dehydrogenase, malate dehydrogenase, and glutamate dehydrogenase) and as a substrate for sirtuins and poly(ADP-ribose) polymerases (PARPs) involved in gene regulation, DNA repair, and cellular stress signaling.

Research models focus on how intracellular NAD+ availability influences multiple pathway contexts, including:

• Redox metabolism and mitochondrial electron transport chain readouts
• Sirtuin-associated gene and protein activity measurements
• PARP-linked DNA damage response datasets
• PGC-1α–associated transcriptional profiles
• Inflammatory signaling components and cytokine expression endpoints

Importantly, PARPs and sirtuins compete for the same intracellular NAD+ pool, with PARPs consuming substantial NAD+ during DNA damage stress, creating a dynamic balance between repair pathways and metabolic regulation. These mechanisms are actively studied in preclinical systems and remain under investigation, with no validated clinical applications for this formulation.

In preclinical research, NAD+ is evaluated across a wide range of concentrations, depending on cell type, experimental duration, and delivery method. Protocols vary significantly across metabolic, mitochondrial, and systems-biology research models.

Reported research observations in preclinical models include the following:

Mitochondrial and Metabolic Models

• Enhanced redox balance markers and oxidative phosphorylation parameters
• Modulation of mitochondrial respiration measurements

Gene Expression and Aging Datasets

• Differential expression patterns in nuclear and mitochondrial gene sets
• Activation of NAD+-dependent signaling pathways (sirtuins, PARPs)

Neurodegeneration-Oriented Models

• Changes in neuronal survival markers and oxidative stress indicators

Inflammation-Related Measurements

• NAMPT-pathway involvement and cytokine-associated signaling readouts

All observations are derived from in vitro or animal research models. No safe or effective dosage has been established for human use.

To maintain compound integrity and experimental reliability:

• Lyophilized Storage: Store at 2–8 °C, protected from light and moisture
• Post-Reconstitution: Refrigerate and minimize freeze–thaw cycles
• Use Window: Apply reconstituted solutions within a research-appropriate timeframe

NAD+ (1000mg) has not been clinically evaluated in this format. Human safety data are unavailable, and the product must only be handled in controlled laboratory research environments.

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC5824497/

https://pmc.ncbi.nlm.nih.gov/articles/PMC9512238/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7442590/

https://www.nature.com/articles/s41392-020-00311-7

https://academic.oup.com/edrv/article/44/6/1047/7207987

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.