Pancragen 50mg

Description

Strength: 50mg
CAS: N/A
Chemical Formula: C₂₆H₃₆N₆O₉
Molecular weight: 576.25 g/mol
Peptide Sequence: Lys-Glu-Asp-Trp (KEDW)
Synonyms: Pancragen Bioregulator
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

Pancragen peptide is a synthetic tetrapeptide bioregulator composed of the peptide sequence Lys-Glu-Asp-Trp (KEDW). It is a synthetic peptide that reproduces the structure of a peptide originally identified in bovine pancreatic tissue extracts and is now produced through controlled chemical synthesis for laboratory research use.

Pancragen has a molecular weight of 576.25 g/mol and a molecular formula of C₂₆H₃₆N₆O₉, placing it within the class of low–molecular-weight organ-specific regulatory peptides described in Khavinson-associated bioregulator research.

The product is supplied as a 50 mg lyophilized powder in a sealed vial and is manufactured to high purity standards, typically ≥95% by chromatographic analysis, with exact purity verified in lot-specific certificates of analysis. Due to its small size, Pancragen has been studied for its ability to enter cells and interact with intracellular and nuclear components involved in gene regulation, a property characteristic of short tetrapeptides in the Khavinson peptide bioregulator class.

In laboratory research, Pancragen has been examined for its role in pancreatic tissue biology, including investigations into endocrine and exocrine pancreatic cell differentiation, age-related pancreatic function, and metabolic regulation. Laboratories that buy Pancragen peptide commonly use this vial size for extended in vitro and preclinical animal research focused on pancreatic aging and glucose metabolism.

• Research-Grade Purity: Manufactured to high purity standards, typically ≥95%, verified by chromatographic analysis
• Lyophilized Powder Format: Stable freeze-dried 50 mg preparation suitable for long-term research storage
• Defined Tetrapeptide Structure: Compact KEDW amino acid sequence with a molecular weight of 25 g/mol
• Pancreas-Focused Research Utility: Studied in pancreatic endocrine and exocrine tissue investigations
• Metabolic Research Relevance: Investigated in laboratory models examining glucose utilization and insulin signaling dynamics
• Gene Expression Research Tool: Examined for involvement in transcriptional regulation associated with pancreatic cell differentiation

For laboratory research use only. Institutions that order Pancragen peptide must restrict use to controlled experimental settings.

Pancragen has been studied as an organ-specific peptide bioregulator that operates primarily through gene regulation mechanisms rather than conventional receptor-binding pathways, though some research describes receptor-mediated modulation of insulin and glucagon signaling as secondary mechanisms.

Experimental studies have examined how this tetrapeptide enters cells and interacts with DNA and chromatin structures, influencing transcriptional activity relevant to pancreatic tissue function.

Reported research applications include:

• Pancreatic Cell Differentiation Studies: Investigated for effects on transcription factors involved in the maturation of endocrine and exocrine pancreatic cells
• Endocrine Pancreas Research: Studied in models examining insulin and glucagon production, pancreatic islet function, and age-related endocrine decline
• Exocrine Pancreas Research: Used to investigate the regulation of digestive enzyme synthesis and acinar cell activity
• Metabolic Regulation Models: Examined in laboratory settings focused on glucose tolerance, insulin dynamics, and metabolic aging
• Cell Aging and Senescence Research: Studied for the modulation of gene expression patterns associated with pancreatic cellular aging
• Epigenetic Research Applications: Investigated for interactions with DNA and chromatin structures that may influence transcriptional activity
• Circadian and Metabolic Signaling Research: Examined for interactions with melatonin receptor signaling pathways and circadian organization of metabolic regulation in pancreatic islet models
• Vascular and Matrix Biology Research: Investigated in rodent models examining endothelial adhesion, capillary permeability, and extracellular matrix remodeling, including involvement of MMP2 and MMP9, in metabolic dysfunction contexts

These applications pertain only to controlled laboratory research contexts.

Published laboratory and preclinical studies describe dosing protocols that vary by model and research objective:

• Non-Human Primate Research: Daily intramuscular doses of 50 μg per animal were administered for 10 consecutive days in aging female rhesus monkeys. Studies reported changes in glucose disappearance rates and alterations in insulin and C-peptide responses during glucose tolerance testing.
• In Vitro Cell Culture Studies: Pancreatic cell cultures exposed to concentrations of approximately 20 ng/mL (Khavinson et al., 2013; MIA PaCa-2 pancreatic acinar cells), with observed changes in expression of pancreatic differentiation markers in both young and aged cell preparations.
• Metabolic Research Observations: Laboratory models with age-related metabolic impairment exhibited glucose tolerance profiles distinct from those of insulin secretagogue activity.
• Timeline-Related Findings: Cellular gene expression changes have been observed during and within defined experimental treatment periods, with persistence varying by endpoint measured.

No standardized dosing exists outside laboratory research environments. All reported data derive exclusively from experimental and preclinical studies.

Store lyophilized Pancragen at –20°C, protected from light and moisture, to preserve peptide integrity. Under frozen conditions at –20°C, lyophilized Pancragen remains stable for extended periods, preserving integrity for long-term research storage. Short-term room-temperature exposure should be limited to brief transport periods.

After reconstitution, avoid repeated freeze–thaw cycles by preparing aliquots. Reconstitution should be performed using appropriate sterile, research-grade solvents under controlled laboratory conditions. Handle all materials using standard laboratory safety and aseptic procedures.

References

https://khavinson.info/assets/files/skan/2016-khavinson_lin_tarn.pdf

https://khavinson.info/assets/files/skan/2015-khavinson_tendler.pdf

https://pubmed.ncbi.nlm.nih.gov/25946840/

https://pubmed.ncbi.nlm.nih.gov/28509500/

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.