Semaglutide 5mg

Semaglutide 5mg is a synthetic GLP-1 receptor agonist peptide developed through recombinant DNA technology, designed to mimic the activity of native human GLP-1. The peptide shares 94% structural homology with human GLP-1(7-37) and contains two critical amino acid substitutions: aminoisobutyric acid (Aib) at position 8 and arginine (Arg) at position 34.

Additionally, lysine at position 26 is modified through acylation with a spacer consisting of glutamic acid and oxyethylene linker moieties, and a C18 fatty di-acid chain. These structural modifications work synergistically: the Aib8 substitution confers resistance to dipeptidyl peptidase-4 (DPP-4) degradation while maintaining receptor potency, while the Lys26 acylation with the C18 fatty di-acid enhances albumin binding and extends the peptide’s half-life in circulation.

It also includes a modified lysine residue linked to a C18 diacid chain. These structural features strengthen resistance to DPP-4 degradation and support extended stability in controlled research environments.

With a molecular weight of 4113.6 g/mol, semaglutide GLP-1 peptide is provided as a high-purity, lyophilized (freeze-dried) powder in a 5 mg vial, designed for laboratory research use. This formulation is commonly used in studies investigating glucose regulation, appetite control, energy metabolism, and metabolic homeostasis in controlled research settings.

• Peptide Sequence: H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(AEEAc-AEEAc-γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-OH

• Chemical Formula: C₁₈₇H₂₉₁N₄₅O₅₉
• CAS Number: 910463-68-2

Researchers who wish to buy semaglutide should know its notable benefits, making it a promising compound. Semaglutide peptide is a valuable tool for laboratory research, offering the following characteristics:

• High Purity: ≥95% purity (verified by HPLC) for consistent and reproducible research results.
• Stable Formulation: Supplied as a lyophilized powder in a semaglutide 5 mg peptide vial for convenient storage and straightforward reconstitution using bacteriostatic water or sterile saline.
• Research Applications: Under investigation for effects on glucose metabolism, insulin secretion, appetite regulation, satiety signaling, and energy balance.
• Extended Stability: The modified structure—combining DPP-4 resistance and albumin-binding fatty acid modification—extends the peptide’s half-life, enabling prolonged research observation periods in controlled laboratory settings.
• Metabolic Research Focus: Supports research in glucose homeostasis, gastrointestinal signaling, neuroendocrine pathways, and systemic metabolic effects.
• Well-Characterized: Absorption, distribution, and binding characteristics are extensively documented in peer-reviewed research literature and structural studies.

Semaglutide activates glucagon-like peptide-1 (GLP-1) receptors, which are expressed in the pancreas, gastrointestinal tract, and brain. In research models, this activation has been associated with the following effects:

• Glucose Metabolism: Studied for its role in stimulating glucose-dependent insulin secretion from pancreatic β-cells and inhibiting glucagon release, contributing to glucose homeostasis in controlled research environments.
• Appetite and Satiety Signaling: Investigated for its effects on hypothalamic appetite-regulating neurons and satiety pathways, which may mediate feeding behavior in animal models.
• Energy Expenditure and Metabolic Rate: Examined for potential effects on thermogenesis, adipose tissue browning, and systemic energy balance in preclinical studies.
• Gastrointestinal and Neuroendocrine Function: Research examines the effects on gastric emptying, nutrient absorption, and the brain-gut signaling axes involved in metabolic regulation.

In research settings, semaglutide is typically tested at varying doses depending on the experimental design and model system:

• Preclinical Models: Rodent studies typically employ doses ranging from 1 to 100 nmol/kg body weight, with commonly used doses between 10–25 nmol/kg for metabolic investigations.
• Clinical Research (Human Studies): Clinical trials typically begin with 0.25 mg administered once weekly, with dose escalation to maintenance doses of 1.0–2.4 mg weekly depending on study protocol and therapeutic endpoints.
• Observed Research Findings: In controlled laboratory and clinical settings, semaglutide has been observed to affect glucose concentrations, insulin and glucagon secretion, appetite-related hormones, and lipid metabolism. These observations are reported in peer-reviewed literature and represent findings in research contexts, not therapeutic claims.

Storage instructions for semaglutide for research peptide involve:

• Lyophilized Powder: Store at 2–8°C in sealed vials, protected from light and moisture. Long-term storage at –20°C is acceptable. Moreover, storing at room temperature is acceptable only during transport or shipping.
• After Reconstitution: Store reconstituted solutions at 2–8°C. Use within 7–10 days for optimal peptide integrity; limit vial punctures and avoid repeated freeze-thaw cycles.
• Handling Requirements: Use appropriate laboratory personal protective equipment, including gloves, eye protection, and a lab coat, when handling the peptide.
• Disposal: Dispose of unused material according to institutional safety protocols and applicable regulations.
• Safety: Always consult and follow the Safety Data Sheet (SDS) provided with the product.

References

https://pmc.ncbi.nlm.nih.gov/articles/PMC5836914/

https://pubchem.ncbi.nlm.nih.gov/compound/Semaglutide

https://pmc.ncbi.nlm.nih.gov/articles/PMC11674233/

https://www.biorxiv.org/content/10.1101/2021.01.12.426449

https://pmc.ncbi.nlm.nih.gov/articles/PMC6474072/

https://www.rcsb.org/structure/4ZGM

https://pdb101.rcsb.org/global-health/diabetes-mellitus/drugs/incretins/drug/semaglutide/semaglutide

https://www.nature.com/articles/s41591-022-02026-4

https://pubmed.ncbi.nlm.nih.gov/39046272/

https://pubmed.ncbi.nlm.nih.gov/34305810/

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.