Tesofensine 30 Capsules 500mcg

Description

Strength: 500mcg
CAS: 195875-84-4
Chemical Formula: C₁₇H₂₃Cl₂NO
Molecular weight: 327.27 g/mol
Synonyms: TE, NS-2330
Storage: Store in a cool, dry place at controlled room temperature. Protect from light and moisture.
Shelf life: 24 months from the manufacturing date.

Tesofensine (500 mcg) is a synthetic compound originally developed for neurological research. Also known as NS-2330, Tesofensine has been studied in research models exploring monoamine transporter activity and central nervous system signaling. Investigations have focused on its potential influence on appetite regulation and metabolic pathways in controlled experimental settings.

Tesofensine remains investigational and is intended strictly for laboratory research use.

• Molecular formula: C₁₇H₂₃Cl₂NO
• Molecular weight: 327.27 g/mol
• CAS number: 195875-84-4
• Purity: High research-grade purity (≥95% typical analytical standard)
• Supplied as: 500 mcg research compound in sealed vial
• Studied in: Central nervous system and metabolic research models
• Stable for: Up to 24 months under proper storage conditions (at 15–25 °C)
• Storage: Store in a cool, dry place at controlled room temperature; protect from light and moisture
• For laboratory research use only

Tesofensine is being investigated as a monoamine reuptake inhibitor (SNDRI) in laboratory settings. Preclinical and early clinical studies have examined its interaction with dopamine, serotonin, and norepinephrine transport systems.

Research applications have included:

• Metabolic regulation studies
• Appetite-related research models
• Central nervous system investigations
• Energy balance research

In controlled experimental environments, Tesofensine has been studied for its effects on neurotransmitter signaling and related metabolic parameters. Research remains investigational and does not establish therapeutic use.

Published research has evaluated Tesofensine in both preclinical models and early-phase human research studies.

Reported experimental dosing has included:

• Milligram-range dosing in early-phase human research studies
• Weight-adjusted dosing in animal models
• Short- to mid-term study durations

Observed research findings have included changes in appetite-related metrics, body weight markers, and neurotransmitter-related endpoints in experimental contexts. These findings are limited to research environments and are not clinical recommendations. No approved therapeutic dosing guidelines exist.

• Store in a cool, dry place at controlled room temperature
• Protect from light and moisture
• Standard shelf life is 24 months when stored under recommended conditions
• Avoid prolonged exposure to humidity
• Handle using appropriate laboratory protective equipment
• Dispose of materials in accordance with institutional chemical safety guidelines

Dispose of materials according to institutional chemical safety guidelines.

References

1. Astrup A, Madsbad S, Breum L, Jensen TJ, Kroustrup JP, Larsen TM. Effect of tesofensine on bodyweight loss, body composition, and quality of life in obese patients: a randomised, double-blind, placebo-controlled trial. Lancet. 2008;372(9653):1906-1913. doi:10.1016/S0140-6736(08)61525-1
2. Axel AM, Mikkelsen JD, Hansen HH. Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology. 2010;35(7):1464-1476. doi:10.1038/npp.2010.16
3. Lehr T, Staab A, Tillmann C, Trommeshauser D, Schaefer HG, Kloft C. A quantitative enterohepatic circulation model: development and evaluation with tesofensine and meloxicam. Clin Pharmacokinet. 2009;48(8):529-542. doi:10.2165/11313370-000000000-00000
4. National Center for Biotechnology Information. PubChem Compound Summary for CID 11370864, Tesofensine. https://pubchem.ncbi.nlm.nih.gov/compound/Tesofensine.

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.