Tirzepatide 100mg

Description

Strength: 100mg
CAS: 2023788-19-2
Chemical Formula: C₂₂₅H₃₄₈N₄₈O₆₈
Molecular weight: 4813.48 g/mol
Peptide Sequence: Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Aib-Leu-Asp-Lys(C20-linker)-Ile-Ala-Gln-Lys-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂
Synonyms: P1206, LY3298176, tirzepatida, tirzepatidum, OYN3CCI6QE
Storage: Store 2–8 °C (≤–20 °C long-term). RT exposure during transport acceptable. Protect from light.
Shelf life: 24 months from the manufacturing date.

Tirzepatide is a synthetic 39-amino acid peptide studied for its dual agonist activity at the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor. In experimental settings, it is examined for its role in metabolic signaling, glucose homeostasis, and energy-balance regulation.

This research-grade formulation is supplied exclusively for laboratory research purposes and is NOT intended for clinical, diagnostic, therapeutic, or any human use.

This compound incorporates proprietary structural modifications that drive its receptor selectivity and extended activity profile. Research programs that buy tirzepatide peptide use this material for controlled laboratory investigations of incretin biology and metabolic signaling pathways.

Tirzepatide peptide is a structurally modified incretin analog engineered for dual-receptor engagement and prolonged systemic exposure in experimental models.

• Peptide length: 39 amino acids
• Peptide classification: Dual GIPR / GLP-1R agonist
• Amino acid sequence (modified):
  YXEGTFTSDYSIXLDKIAQKAFVQWLIAGGPSSGAPPPS-NH₂
• Structural modifications:
  • α-Aminoisobutyric acid (Aib) at positions 2 and 13
  • C20 fatty diacid conjugate at Lys20 via γ-glutamic acid + bis-AEEA linker
  • C-terminal L-serinamide
• Molecular formula: C₂₂₅H₃₄₈N₄₈O₆₈
• Molecular weight: 4810.52 Da
• PubChem CID: 156588324
• Receptor selectivity: GIPR-preferential with GLP-1R activity
• Signaling profile: Biased agonism favoring cAMP pathways
• Format: Pharmaceutical-grade lyophilized peptide

Regulatory status: For laboratory research use only. It is available to qualified researchers who order tirzepatide peptide from authorized suppliers

In experimental systems, tirzepatide is studied for coordinated incretin receptor signaling rather than isolated receptor activation.

Mechanistic endpoints commonly evaluated include:

• Glucose-dependent insulin secretion in pancreatic β-cells
• Reduction of β-cell apoptosis under metabolic stress conditions
• Dose-dependent glucagon modulation, dependent on ambient glucose levels
• Biased agonism, with preferential activation of cAMP-mediated signaling over β-arrestin recruitment
• Gastric motility and appetite regulation, examined through vagal nerve signaling and central nervous system pathways
• Energy metabolism effects, including adipose tissue insulin sensitivity and triglyceride regulation
• Albumin binding via C20 fatty diacid conjugation, contributing to extended half-life (~5 days) in animal models

Tirzepatide is supplied exclusively for laboratory research and may be used in:

• Pancreatic islet and β-cell function studies
• Incretin receptor pharmacology, including cAMP assays and β-arrestin recruitment profiling
• Glucose homeostasis models, including OGTT, IPGTT, and insulin tolerance testing
• Central appetite regulation and energy-balance signaling
• Adipose tissue metabolism and insulin signaling cascades
• Lipid metabolism and cardiometabolic risk factor studies
• Renal function and metabolic nephroprotection models
• Biased agonism and structure–function relationship analysis
• Combination pharmacology and drug–interaction studies in controlled systems

Tirzepatide contains a C20 fatty diacid conjugate that is susceptible to oxidation, hydrolysis, and aggregation when improperly handled.

Lyophilized (Unopened)

• –80 °C: Preferred for 1+ year storage
• –20 °C: Stable for 6–24 months
• 2–8 °C: Up to 4 weeks for active research use
• Store sealed, protected from light and moisture

Reconstituted Solution

• Maintain at 2–8 °C
• Optimal use within 24–72 hours
• May extend to 7 days if sterile and protected from light
• Avoid freeze–thaw cycles
• Minimize temperature fluctuation

Visual Inspection Guidance

• Pale yellow coloration: Acceptable, linked to fatty-acid conjugation
• Brown or dark discoloration: Suggests oxidative degradation
• Cloudiness or particulates: Indicates aggregation or contamination

References

https://pubmed.ncbi.nlm.nih.gov/35333651/

https://pmc.ncbi.nlm.nih.gov/articles/PMC7526454/

https://pmc.ncbi.nlm.nih.gov/articles/PMC10115620/

https://pubmed.ncbi.nlm.nih.gov/34003802/

Compliance Notice

This product is intended for laboratory research use only and is not approved for human or veterinary use.