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What are the Differences Between Belotero Dermal Filler vs Juvederm?

Jun 20, 2018

What is Belotero?

Belotero is a collection of non-permanent soft tissue fillers manufactured by Merz Pharmaceuticals. These fillers are composed of cross-linked synthetic hyaluronic acid gel that is processed using 2 patented technologies: Cohesive Polydensified Matrix (CPM) and Dynamic Cross-Linking Technology (DCLT). The resulting monophasic fillers have varying concentrations of hyaluronic acid and viscoelasticity to treat a wide range of skin imperfections—from skin dullness to severe loss of facial volume.

What is Juvederm?

Juvederm is another range of soft tissue fillers made from cross-linked non-animal hyaluronic acid manufactured by Allergan. The gel is processed using 2 different manufacturing technologies—Vycross and Hyalacross—to give rise 2 collections of implants: the Vycross and Ultra. Both of these ranges have varying hyaluronic acid concentrations as well as viscoelastic properties. These aesthetic solutions are used to treat a lot of skin problems such as dryness and even sunken areas. 

Similarities and differences between Belotero vs Juvederm


Hyaluronic acid actually exists naturally in the skin to provide much-needed hydration for other cells. Hyaluronic acid-based dermal fillers are a popular choice due to their safety and efficacy. Both of these brands share the same type of filler material—cross-linked synthetic hyaluronic acid. The molecules are extracted and purified from fermenting bacteria cultures. Besides that, these 2 brands are proven to last approximately a year once administered into problematic skin areas. They are biodegradable and bioresorbable and will be eventually disintegrated into the surrounding tissues, making them non-permanent aesthetic fillers. In addition, the hyaluronic acid gel from both these brands have a monophasic homogenous texture. They are highly cohesive and can integrate seamlessly with the facial tissues to deliver natural-looking aesthetic improvements.


A major difference is the technology used to cross-link hyaluronic acid molecules. Belotero is processed using DCLT. This proprietary technology double cross-links hyaluronic acid strands with non-crosslinked molecules. The resulting gel then has an ideal balance of cohesivity, elasticity, and plasticity. On the other hand, Vycross Technology produces fillers that contain majority (90%) low molecular weight and minority (10%) of high molecular weight hyaluronic acid. Another technology used by Juvederm brand is Hyalacross Technology. This advanced manufacturing process ensures that the fillers possess very smooth gel consistencies.

Read more about Juvederm