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Last Updated On March 29, 2024

What is Euflexxa Injection Used For?: Side Effects and Dosage

Apr 23, 2018

What is Euflexxa?

You can buy Euflexxa as an injectable made of sodium hyaluronate or hyaluronic acid (HA), which is indicated for the treatment of pain associated with knee osteoarthritis (OA). Patients who have failed to experience adequate relief from simple pain relievers and non-pharmacologic therapy are good candidates for this treatment. The safety profile of Euflexxa has been established for up to 1 year.

How this injection works

Viscosupplementation of synovial joints with osteoarthritis has been found to have significant potential benefits. In the United States, intra-articular injection of hyaluronic acid is only approved for knee arthritis, but in other parts of the world, it is approved for other types of painful joint arthritis.

Euflexxa can relieve joint pain by lubricating the joints, allowing greater mobility and flexibility, thereby reducing pain in the affected joint.


Each syringe of Euflexxa injectable is made of 20mg sodium hyaluronate, 17mg sodium chloride, 1.12mg disodium hydrogen phosphate dodecahydrate, 0.1mg sodium dihydrogen phosphate dehydrate, and water.


  • Patients with blood coagulation problems or are taking anti-coagulant medications
  • Patients with bacterial infection of underlying tissues
  • Patients with active skin lesions or psoriatic skin plaques
  • Pregnant or lactating women
  • Patient with known history of multiple or severe allergic reactions

Step-by-step Procedure

  1. Obtain a thorough medical history of your patients to determine if they are good candidates for Euflexxa injection.
  2. Explain the whole procedure, side effects, and complications.
  3. Have them sign an informed consent.
  4. Position the patient.
  5. Clean and mark the injection site.
  6. Prepare the materials and administer a local anaesthetic if needed.
  7. Aspirate if joint effusion is present.
  8. Inject the whole contents of 1 syringe in 1 knee.
  9. If treating both knees, use a separate syringe for each joint.
  10. Discuss post-procedure care.


Standard dosage for Euflexxa injection is 1 to 2mL (20mg/2mL) into 1 knee or other synovial joints once a week for 3 weeks.

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Euflexxa Side Effects

Side effects associated with Euflexxa injection are often mild and self-limiting. Post-injection reactions such as swelling, redness, and bruising can be minimised by applying ice pack on the treated joint. Although rare, hypersensitivity reactions may still occur. The injector and patient must watch out for symptoms of itching, rash, nausea, and difficulty of breathing.

Most common side effects:

  • Back pain
  • Arthralgia
  • Joint swelling
  • Localised pain or tenderness
  • Musculoskeletal pain

Potential rare effects:

  • Infection
  • Serious allergic reaction symptoms (rare): rash, itching, swelling of the face, tongue or throat, dizziness, breathing problems
  • Joint effusion

*Disclaimer:  Information on Maylips.com is provided for informational purposes only. Self-medication is strictly prohibited. All aesthetic procedures should be provided by the licensed healthcare specialist after the consultation with the personal therapist. The information in this article should not be used for prescribing any medication for the beauty injections.

All brand and medication descriptions in the article are based on the personal opinion and are not endorsed by Maylips.com. The article content was not reviewed for medical validity. Use this article for information and not for a final decision on the procedure.