RENEFIL DEEP PLUS

RENEFIL DEEP PLUS is a hyaluronic acid-based dermal filler enhanced with polynucleotides (PN) and lidocaine for patient comfort. It belongs to the RENEFIL hybrid filler portfolio and is specifically formulated for treating moderate to deep wrinkles and restoring volume in the mid-face.

• Type: Cross-linked HA + PN + Lidocaine hybrid dermal filler

• Use: Injectable treatment for volume loss, folds, and skin texture improvement

• Delivery: Comes in a prefilled, sterile syringe with 2 needles

RENEFIL DEEP PLUS is engineered to deliver both volumizing and skin-rejuvenating effects. Its unique HA-PN hybrid structure provides enhanced elasticity, cohesiveness, and long-lasting results.

• Combines mechanical lift with biological regeneration

• Improves skin texture by stimulating collagen and hydration

• Long-lasting volume retention: up to 12–14 months in studies

• Low injection force ensures smoother application

• Uses patented 4L™ Technology for low BDDE content and safety

This filler is composed of three main active components, each contributing a specific function in the treatment outcome.

• Cross-Linked Hyaluronic Acid (CL-HA) – 20 mg/mL

  • Provides structural volume and supports skin scaffolding

• Sodium Polynucleotide (PN) – 1.875 mg/mL

  • Enhances tissue repair, fibroblast activity, and collagen production

• Lidocaine Hydrochloride – 0.3% (3 mg/mL)

  • Reduces discomfort during injection

RENEFIL DEEP PLUS is indicated for moderate to deep wrinkle correction and facial volume restoration in adults. Its formulation allows both physical lifting and dermal regeneration.

• Corrects nasolabial folds, marionette lines, and mid-face volume loss

• Supports contouring of areas such as the cheeks, chin, and temples

• Designed to visibly reduce signs of aging and restore youthful fullness

The product is administered into the deep dermis or subcutaneous layer, depending on the treated area and the injector’s technique.

• Recommended injection sites include:

  • Nasolabial folds

  • Cheeks (malar zone)

  • Chin and jawline

  • Temples and zygomatic arch

• Suitable for use with a 27G or 30G needle, depending on injector preference

RENEFIL DEEP PLUS is supplied as a ready-to-use product and does not require dilution or reconstitution. Aseptic technique is essential during handling.

• Supplied in a 1.0 mL prefilled syringe

• Each unit includes 2 sterile needles

• Do not mix with other fillers or substances before injection

• Use only under sterile conditions by qualified professionals

Administration should be carried out by trained professionals familiar with dermal filler techniques. Dosage varies depending on the treatment area and patient needs.

• Inject slowly into the deep dermal or subcutaneous plane

• Maximum dose per session should follow clinical judgment

• Inject small aliquots, mold if necessary, and monitor for symmetry

• Avoid overcorrection; product is intended to be layered gradually

Proper storage preserves product stability and patient safety.

• Store at 2°C to 25°C (36°F to 77°F)

• Keep in original packaging to protect from light

• Do not freeze

• Single-use only—discard any unused product after opening

RENEFIL DEEP PLUS should not be used in patients with known allergies or certain medical conditions.

• Hypersensitivity to hyaluronic acid, lidocaine, or any component

• Autoimmune disorders or chronic inflammatory conditions

• Active infections at the injection site (e.g., herpes, abscess)

• Pregnancy or breastfeeding

• Patients with bleeding disorders or on anticoagulants

Careful consideration must be given to patient history and injection technique to avoid complications.

• Avoid intravascular injection to prevent embolism or ischemia

• Do not use in combination with laser, ultrasound, or peeling treatments in the same session

• Ensure correct anatomical knowledge to minimize side effects

• Not recommended for patients under 18 years old

Proper aftercare improves outcomes and reduces risks.

• Avoid massaging the area unless advised

• No makeup, alcohol, or intense physical activity for 24 hours

• Avoid UV exposure, extreme cold or heat for several days

• Report any unusual swelling or pain to the provider promptly

Side effects are generally mild and temporary but should be monitored.

• Common: Redness, bruising, swelling, pain, or itching at the injection site

• Rare: Lumpiness, nodule formation, or asymmetry

• Severe (but uncommon): Intravascular complications, infection, or delayed granuloma

• Report any unexpected or prolonged reactions to the regulatory authority or manufacturer

Patient selection is critical for safe and effective outcomes.

• Suitable for adults over 18 years with facial volume loss or wrinkles

• Patients must be in good general health

• Not recommended for individuals with compromised immunity, skin disorders, or recent facial surgery

Ongoing treatments may be required to maintain optimal results.

• Results typically last up to 12–14 months depending on area and metabolism

• Follow-up sessions may be scheduled every 9–12 months

• Top-up treatments may be needed for asymmetry or correction

RENEFIL DEEP PLUS is developed by BMI Korea Co., Ltd., a CE-certified manufacturer operating under ISO 13485 standards.

• Manufacturer: BMI Korea Co., Ltd., Jeju, South Korea

• CE Certificate: No. 2020-MDD/05-095

• Patents registered in Korea, USA, EU, China, Russia, and Japan

• Batch code and expiry date printed on each unit

What makes RENEFIL DEEP PLUS different from other fillers?
It combines HA and PN to offer both lifting and skin rejuvenation in one syringe.

How long do results last?
Clinical and animal studies show effects may last up to 56 weeks (1 year+).

Is it safe?
Yes, it has CE certification, minimal BDDE content, and strict manufacturing controls.

Who can inject RENEFIL DEEP PLUS?
Only licensed medical professionals trained in dermal filler procedures.

Can it be used with other treatments?
Not within the same session as lasers or chemical peels. Always space out procedures.