STYLAGE® M BI-FLEX® with Lidocaine

Description

Name: STYLAGE® M BI-FLEX® with Lidocaine
Manufacturer: Vivacy
Active Substance(s): CROSS-LINKED HYALURONIC ACID (HA), MANNITOL, LIDOCAINE
Strength: 20mg/g HA, 9mg/ml Mannitol, 3mg/ml Lidocaine
Package Content: 2 x 1ml Pre-Filled Syringes, 2 x 30 G ½ Needles

STYLAGE® M BI-FLEX® with Lidocaine is an injectable hyaluronic acid dermal filler developed by Laboratories VIVACY in France. Formulated with 20mg/g cross-linked hyaluronic acid, 9mg/mL mannitol, and 3mg/mL lidocaine, it combines IPN-Like Technology™, mannitol-enhanced longevity, a patented syringe system formerly known as Bi-SOFT®, and a versatile BI-FLEX® rheological profile. Designed for moderate wrinkle correction, volume restoration, and hand rejuvenation, the product is supplied as 2 × 1mL prefilled syringes with 2 × 30G ½ needles. Practitioners seeking to buy STYLAGE® M BI-FLEX® with Lidocaine online may contact Maylips support team for guidance.

• Strength: 20mg/g HA | 9mg/mL Mannitol | 3mg/mL Lidocaine
• Active Ingredient: Hyaluronic acid (cross-linked) 20mg/g; Mannitol 9mg/mL; Lidocaine 3mg/mL
• Dosage Form: Injectable gel — 2 × 1mL prefilled syringes (patented syringe system; formerly known as Bi-SOFT®) + 2 × 30G ½ needles
• FDA Approval Date: STYLAGE® is NOT FDA-approved for U.S. use. The product carries CE marking for European Union markets only (CE certification for medical devices under the EU MDR).
• Molecular Type: Cross-linked hyaluronic acid (IPN-Like Technology™) with mannitol and lidocaine
• Intended Use: Moderate wrinkle correction, volume restoration, hand rejuvenation. Only for use by licensed aesthetic professionals
• Brand: STYLAGE®
• Country of Origin: France
• Manufacturer: Laboratories VIVACY (Paris, France)

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STYLAGE® M BI-FLEX® with Lidocaine is engineered to deliver predictable correction and smooth tissue integration across multiple treatment areas. It differentiates itself through four core pillars: advanced cross-linking technology, antioxidant defense, ergonomic delivery, and integrated anesthesia.

IPN-Like Technology™ & Rheological Versatility

The foundation of the formulation is IPN-Like Technology™, which consists of two distinct, interlocked hyaluronic acid (HA) networks. Compared to conventional single-network HA fillers, this design delivers:

• Enhanced Cohesivity & Elasticity: The gel better resists mechanical stress and deformation.
• Structural Integrity: It maintains its shape and placement post-implantation.
• Versatile BI-FLEX® Profile: It adapts fluidly across varied facial treatment areas and subcutaneous hand rejuvenation, allowing injectors to address diverse aesthetic concerns with a single product.

Antioxidant Defense (9mg/mL Mannitol)

Unlike standard HA fillers that lack antioxidant protection, STYLAGE® includes mannitol to act as a potent free radical scavenger.

• Reduces Degradation: It shields the HA gel from the immediate oxidative stress triggered by the injection process.
• Sustains Longevity: By minimizing early breakdown, mannitol supports a longer-lasting correction outcome.

Ergonomic BI-FLEX® Delivery System

The gel is housed in a patented syringe system (formerly marketed as Bi-SOFT®).

• Enhanced Injection Control: Designed for optimal ergonomics and stability in the hand.
• Consistent Flow Rate: Minimizes extrusion force, allowing the practitioner greater precision during micro-droplet placement.

Co-Formulated Anesthesia (3mg/mL Lidocaine)

To optimize patient comfort, lidocaine is integrated directly into the cross-linked HA matrix. This provides rapid local anesthesia during the injection process without the routine need for separate topical or nerve block procedures.

STYLAGE® products carry the CE mark for professional aesthetic use within European Union markets. Because regulatory frameworks vary globally, practitioners must independently verify the legal and importation status of this product within their specific jurisdiction prior to procurement.

STYLAGE® M BI-FLEX® with Lidocaine is indicated for correction of moderate facial wrinkles, restoration of lost volume, and hand rejuvenation procedures performed by qualified medical professionals. Common treatment areas include:

• Deep wrinkles, nasolabial folds, and marionette lines (mid-dermis placement)
• Cheeks, chin, and lips filler applications (mid-to-deep dermis)
• Dorsum of the hands for hand rejuvenation (subcutaneous placement)

Hand rejuvenation is a distinctive indication for this STYLAGE® dermal filler. Correcting the volume loss on the dorsum of the hands can improve the visibility of tendons and bony structures that become more prominent with age.

Patient selection should account for degree of volume loss, skin quality and condition of the patient’s skin, treatment area characteristics, and factors such as skin type. STYLAGE® M BI-FLEX® with Lidocaine is intended exclusively for licensed aesthetic medicine professionals; self-administration is contraindicated.

Cross-linked hyaluronic acid binds and retains water molecules within the dermis following implantation, producing immediate volumization and wrinkle correction. IPN-Like Technology™ enhances cohesivity and elasticity through interlocked polymer networks that resist deformation and support long-term structural stability, contributing to smoother tissue integration and sustained correction outcomes.

Mannitol provides antioxidant support by scavenging free radicals that promote hyaluronic acid degradation, potentially extending filler longevity beyond standard HA formulations. The co-formulated lidocaine (3mg/mL) modulates pain signaling during injection, improving treatment comfort without requiring a separate anesthetic step.

Like all hyaluronic acid-based fillers, STYLAGE® M BI-FLEX® with Lidocaine is fully reversible through hyaluronidase administration when correction, adjustment, or emergency dissolution is required.

STYLAGE® M BI-FLEX® with Lidocaine injection should only be performed by qualified medical professionals experienced in facial anatomy and injectable procedures. Recommended injection depth is mid-dermis for wrinkle correction and subcutaneous for volume restoration and hand rejuvenation. Following treatment, patients should avoid excessive sun exposure until redness, swelling, and tenderness have resolved.

Common Side Effects

Common post-treatment reactions include redness, swelling, tenderness, bruising at the injection site, mild discomfort, and temporary firmness within the treated area. These reactions are generally temporary and typically resolve within a few days, though recovery time may vary depending on the treatment area and factors such as skin type.

Serious Adverse Events

Although rare, serious complications may occur, including vascular occlusion, skin necrosis, infection, and hypersensitivity reactions. Practitioners should remain familiar with emergency complication protocols and the appropriate use of hyaluronidase. Patients with known hypersensitivity to hyaluronic acid or amide-type local anesthetics should be carefully evaluated before treatment.

Clinicians should consult the product Instructions for Use (IFU) for complete safety guidance.

STYLAGE® M BI-FLEX® with Lidocaine is manufactured by Laboratories VIVACY in France and is CE-marked for professional aesthetic use within applicable European markets. Current FDA approval status and regional regulatory requirements should be independently verified before procurement or clinical use in the United States or other jurisdictions. Practitioners who wish to buy dermal fillers or buy STYLAGE® may contact Maylips support team for sourcing information and documentation support.

For sourcing guidance, contact Maylips support team.

Regulatory information current as of mid 2026. Practitioners should confirm local regulatory status before sourcing.