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Polynucleotides
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Last Updated On February 4, 2025

Polynucleotides Ingredients – Understanding the Composition of Polynucleotides

Jan 29, 2025

Recent advancements in aesthetic medicine have highlighted the potential of polynucleotides in skin rejuvenation. Studies show that these DNA- and RNA-derived molecules can enhance skin texture, reduce wrinkle depth, and promote a youthful appearance. Their ability to stimulate collagen production and accelerate tissue repair has made them increasingly popular among aesthetic practitioners.

Polynucleotides are biologically derived molecules extracted from purified fish DNA. They work by restoring skin structure, reducing inflammation, and improving skin quality. Their natural ability to stimulate cell regeneration makes them a sought-after treatment in non-surgical aesthetics.

In this article, we will explore the key ingredients of polynucleotides, their role in skin rejuvenation, and why they are becoming a leading choice in regenerative aesthetics.

Key Takeaways

  • Polynucleotides promote skin regeneration by stimulating collagen production, improving skin elasticity, and providing deep hydration.
  • Botox temporarily paralyzes muscles to reduce wrinkles, primarily targeting dynamic lines caused by muscle movement.
  • Polynucleotides are ideal for skin rejuvenation, while Botox is more suitable for treating expression lines.
  • Polynucleotides offer longer-lasting, natural-looking results, while Botox results typically last 3 to 6 months.
  • Both treatments can be used together for a more comprehensive skin rejuvenation plan, with different mechanisms addressing various aspects of aging.
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Active Ingredients in Polynucleotides

Polynucleotides are long chains of nucleotides, the building blocks of DNA and RNA, often derived from salmon sperm or yeast. These naturally occurring molecules stimulate fibroblast activity, promoting collagen production and enhancing skin elasticity, texture, and hydration. They also increase cell turnover, supporting faster healing and skin regeneration. This process leads to overall skin rejuvenation and improved skin quality.

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  • Nucleotides (DNA and RNA building blocks): Essential for cellular repair and regeneration. When used in polynucleotide treatments, they help promote DNA and RNA synthesis, supporting the repair of damaged skin cells and encouraging healthy cell turnover.
  • Collagen-stimulating peptides: These peptides signal the skin’s fibroblasts to produce more collagen, a protein that gives skin its structure and firmness. Increased collagen helps improve skin elasticity, reduce fine lines, and restore a youthful appearance.
  • Hydration-promoting compounds: Enhance the skin’s ability to retain moisture, improving hydration levels. Keeping the skin well-moisturized, they help maintain a plump, smooth texture and reduces the appearance of dry, dull skin.

These elements improve skin structure and appearance, delivering a more youthful look.

Benefits of Nucleotides

Nucleotides are vital for skin regeneration and collagen synthesis, supporting cellular repair and DNA synthesis to restore damaged skin. When used in polynucleotide treatments, they stimulate collagen and elastin production, which is essential for skin firmness and elasticity. This process improves the skin’s overall texture and helps maintain hydration, contributing to a more youthful appearance. Its benefits include:

  • Stimulate the production of collagen and elastin
  • Promote cellular repair and skin regeneration
  • Increase skin hydration levels
  • Improve skin tone and resilience

These advantages make polynucleotides an effective choice for individuals seeking non-invasive skin rejuvenation.

Safety and Efficacy

Polynucleotides have gained significant attention in aesthetic medicine due to their regenerative properties and safety. Various reviews highlight their ability to regulate gene expression and improve skin texture and elasticity. Derived from natural sources, such as salmon DNA, they enhance skin hydration and support tissue renewal.

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Likewise, clinical trials show that polynucleotide fillers are more effective than hyaluronic acid fillers in correcting crow’s feet. Additionally, studies on Asian skin types have demonstrated the benefits of polynucleotide High-Purification Technology (PN HPT) in improving overall skin quality. These findings underscore the growing potential of polynucleotides as a powerful treatment for achieving youthful, rejuvenated skin.

Compared with Other Skin Rejuvenation Treatments

Polynucleotides offer a regenerative approach to skin rejuvenation, focusing on collagen production and skin renewal. Between polynucleotides vs Botox, dermal fillers, and hyaluronic acid, which target specific symptoms like wrinkles or volume loss, polynucleotides improve overall skin quality by stimulating natural tissue regeneration. Specifically, these treatments present the following key differences:

  • Polynucleotides: Promote collagen and elastin production for improved skin quality.
  • Botox: Relaxes muscles to reduce dynamic wrinkles.
  • Dermal Fillers: Add volume, targeting areas with volume loss.
  • Hyaluronic Acid: Hydrates and plumps skin without promoting regeneration.

Polynucleotides provide a more holistic, regenerative approach to skin rejuvenation.

Conclusion

Polynucleotides are a natural and effective option for skin rejuvenation, promoting collagen production, hydration, and improved texture. Unlike Botox and dermal fillers, which target specific wrinkles or volume loss, polynucleotides offer a more holistic, non-invasive approach to skin health. They are an excellent choice for skin rejuvenation with minimal downtime and long-lasting results. 

FAQs

1. How do polynucleotides work for skin rejuvenation? 

Polynucleotides work by stimulating the skin’s natural collagen production, improving elasticity, texture, and hydration, helping to restore youthful skin appearance.

2. What areas can be treated with polynucleotides? 

Common treatment areas include the face, neck, décolletage, under-eye area, hands, and jawline.

3. Can polynucleotides be used in combination with other treatments? 

Yes, polynucleotides can be combined with other treatments like Botox, dermal fillers, or laser treatments to enhance skin rejuvenation.

4. Who is a good candidate for polynucleotide treatments? 

Ideal candidates are those with aging skin, dull complexion, fine lines, or sagging. It’s important to have realistic expectations and be in overall good health.

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References

Lee KWA, Chan KWL, Lee A, et al. Polynucleotides in Aesthetic Medicine: A review of current practices and Perceived effectiveness. International Journal of Molecular Sciences. 2024;25(15):8224. doi:10.3390/ijms25158224
Pu SY, Huang YL, Pu CM, et al. Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis. Nutrients. 2023;15(9):2080. doi:https://doi.org/10.3390/nu15092080