two photos showing patient's lines in the nose up to the chin
Polynucleotides
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Last Updated On February 9, 2025

Polynucleotides Marionette Lines – Treating Marionette Lines with Polynucleotides

Jan 31, 2025

Marionette lines, which extend from the corners of the mouth to the chin, become more pronounced with age as collagen and elastin levels decline. These lines are a common sign of aging, often giving the face a sagging or downturned appearance.

Polynucleotide treatments are gaining popularity as an effective solution for marionette lines and other age-related concerns. By stimulating skin repair and rejuvenation, polynucleotides help improve elasticity, enhance texture, and restore a firmer, more youthful look.

In this article, we will explore the effectiveness of polynucleotide treatments for marionette lines, highlighting visible before-and-after improvements in skin quality.

Key Takeaways

  • Polynucleotides provide a non-invasive solution for reducing marionette lines, offering an alternative to surgical procedures.
  • The treatment stimulates collagen production, improving skin elasticity and firmness around the mouth and chin.
  • By deeply hydrating the skin, polynucleotides help create a smoother, plumper complexion.
  • Results appear subtle and natural, enhancing facial contours without drastic changes.
  • With minimal downtime, patients can resume daily activities quickly after treatment.
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What Are Marionette Lines?

Marionette lines are the deep lines or folds that form around the mouth and chin, resembling the strings of a marionette puppet. These lines run from the corners of the mouth to the jawline, creating a more downturned, tired, or sad appearance.

sad about her under eyes

Marionette lines typically develop with age as the skin loses elasticity and collagen production decreases. Factors such as repetitive facial expressions, genetics, and sun exposure can affect their formation. As we age, the skin becomes thinner and less able to resist the forces of gravity, leading to sagging and the development of these lines. 

While they are most commonly associated with aging, other lifestyle factors, like smoking or dehydration, can also accelerate the process.

How Polynucleotides Help

Polynucleotides (PN) contain DNA fragments, often used in aesthetic medicine to rejuvenate the skin. They stimulate collagen production and improve skin hydration, which is vital for addressing marionette lines.

When injected into the skin, polynucleotides promote the regeneration of skin cells and encourage the production of new collagen fibers. Collagen is essential for skin structure and elasticity, and its stimulation helps to restore the skin’s firmness, reducing the depth of marionette lines.

Polynucleotides also have hydrophilic (water-attracting) properties, which improve skin moisture and plumpness. This, in turn, gives the skin a smoother, more youthful appearance. The procedure provides a natural, long-lasting solution for reducing marionette lines without requiring invasive surgery or synthetic fillers.

Treatment Areas

The area surrounding the mouth and chin is the primary focus for treating marionette lines with polynucleotides. Here are the best places for injection:

marionette lines injection
  • Corners of the Mouth: This is where the marionette lines typically begin. Injecting polynucleotides in this area helps to reduce the appearance of the deep folds and restores a youthful contour to the smile.
  • Jawline: The jawline is another key area for treating sagging skin, particularly in combination with the marionette lines. This can help create a more defined, lifted look.
  • Nasolabial Folds: Though not technically marionette lines, the nasolabial folds (lines running from the nose to the corners of the mouth) are often treated simultaneously to create a more cohesive result when addressing lower face wrinkles.

Polynucleotide injections are generally performed in these targeted areas to stimulate collagen production, tighten the skin, and smooth out wrinkles.

Expected Results

After treatment with polynucleotides, you can expect smoother skin and a reduction in the depth of marionette lines over time. The collagen stimulation process takes a few weeks to show noticeable effects, but the results can last several months, depending on your skin’s response and overall skincare routine. Here’s what you can expect from the results:

  • Smoother Skin Texture: As collagen rebuilds and the skin retains moisture, marionette lines become less pronounced.
  • Restored Youthful Contours: Polysaccharide injections help restore a lifted and rejuvenated look by tightening sagging skin around the mouth and chin.
  • Natural-Looking Results: The treatment works with your body’s natural healing process, so the results are subtle and harmonious with the rest of your facial features.

Patients may ask, “how many polynucleotide treatments are needed?” In some cases, more than one treatment session may be necessary to achieve optimal results, but after the entire treatment, the skin should appear firmer and more youthful, with diminished lines and improved texture.

Conclusion

Polynucleotides provide a non-surgical solution for treating marionette lines by stimulating collagen production and improving hydration. This treatment can restore a youthful appearance around the mouth and chin.

FAQs

1. What are polynucleotides?

Polynucleotides are DNA-derived molecules used in skincare to promote skin regeneration, hydration, and elasticity. They work at a cellular level to repair damaged skin and improve overall skin quality.

2. How do polynucleotides benefit the skin?

Polynucleotides enhance collagen production, improve skin hydration, and accelerate tissue repair. They help reduce wrinkles, improve skin texture, and restore a youthful glow.

3. How long does it take to see results?

Results vary, but most people notice improved hydration and radiance within a few weeks. Long-term benefits, like increased collagen production and wrinkle reduction, become visible over time.

4. Can polynucleotides be combined with other treatments?

They can be used alongside hyaluronic acid, microneedling, and other anti-aging treatments to enhance results.

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References

Marionette Lines: What They Are, Causes, Filler, & Treatments. Cleveland Clinic. https://my.clevelandclinic.org/health/diseases/23028-marionette-lines 
Marionette Lines: Causes and Proven Treatments for Chin Wrinkles. Healthline. Published July 23, 2020. https://www.healthline.com/health/beauty-skin-care/marionette-lines