SHARE THIS ARTICLE
Polynucleotides
Polynucleotides How Many Treatments – Recommended Treatment Regimen
Jan 30, 2025
Polynucleotide treatments have gained attention for their ability to revitalize the skin by stimulating collagen production. Derived from natural sources like salmon DNA, they help enhance hydration, refine texture, and reduce fine lines, making them a sought-after option for non-surgical skin rejuvenation. Research suggests that a structured treatment plan leads to progressive and long-lasting improvements in skin quality.
These biocompatible molecules made up of long chains of nucleotides, work at a cellular level to promote skin regeneration with minimal side effects. Their ability to repair and strengthen the skin barrier makes them an effective choice for those looking to restore a youthful, healthy complexion.
In this article, we’ll break down the recommended treatment regimen for polynucleotides, including how many sessions are typically needed and what kind of results you can expect.
Key Takeaways
- To achieve optimal results, most individuals require 2-3 sessions of polynucleotide treatment, spaced about 2-4 weeks apart. This allows the skin to respond to the treatment’s regenerative effects.
- After the initial cycle, maintenance treatments are typically recommended every 6-12 months, depending on individual skin needs and desired results.
- The treatment regimen can be customized based on age, skin condition, and the specific concerns being addressed, such as fine lines, wrinkles, or skin laxity.
- Results from polynucleotide treatments generally take time to become fully visible, with improvements in skin texture, elasticity, and firmness often becoming noticeable after 1-2 months.
- The benefits of polynucleotide treatments, such as improved skin quality and reduced sagging, can last up to a year, making maintenance treatments necessary for long-term skin rejuvenation.
About: Trusted by over 2,000+ global clients since 2014, Maylips has become a leading supplier of cosmetic, skincare, and orthopedic products for medical and aesthetic professionals. Maylips offers a wide range of authentic brand-name products at competitive wholesale prices, sourced from around the world. If you’re looking to buy Nucleotides online, contact our sales team for guidance.
Treatment Frequency
Polynucleotide treatments promote skin regeneration and healing by stimulating cell turnover and collagen production. These treatments are increasingly popular for skin rejuvenation, wound healing, and aesthetic concerns such as polynucleotides for jowls. A typical regimen usually involves 3-5 sessions to achieve the best results, with enough time for the body to recover and respond to the treatment.

- Initial Phase: The first few sessions are spaced 1-2 weeks apart, allowing the body to adapt and begin healing.
- Maintenance Phase: After the initial sessions, treatments are spaced further apart, typically 3-4 weeks, to maintain results and support ongoing regeneration.
- Results: Most patients see noticeable improvements after the second or third session, with full results emerging after the final treatment.
The exact number of sessions may vary based on individual factors like age, skin condition, and health.
Adjustment Based on Patient Needs
Each patient’s needs are unique, so the treatment regimen should be tailored to their specific concerns and goals. Factors such as skin type, the severity of the issue being treated, and previous medical history can all influence the number and frequency of treatments. Here’s how to adjust the plan accordingly:
- Skin Condition: Severe skin issues, like deep wrinkles or sun damage, may require more treatments to achieve significant healing. Milder concerns often respond well with fewer sessions for satisfactory results.
- Age: Older patients may need more treatments due to the decline in the skin’s regenerative capacity. Younger patients tend to see faster, more noticeable improvements with fewer sessions.
- Health Status: Patients with conditions like diabetes or immune system issues may require treatment frequency or extra monitoring adjustments to ensure effectiveness and safety.
- Treatment Area: Larger or more complex treatment areas (e.g., neck, chest) may require additional sessions. More minor, targeted areas, like the face, typically need fewer treatments for optimal results.
Ultimately, regular assessment during the treatment process helps to adjust the plan for each patient’s evolving needs.
Follow-Up and Maintenance
After the initial series of treatments, follow-up and maintenance sessions are crucial to preserving the results. The frequency of these sessions will depend on the patient’s specific response to treatment and desired outcomes.

- First Follow-Up: Generally, a follow-up session should be scheduled about 4-6 weeks after the final treatment in the initial series. This allows the body to respond to the polynucleotides fully, and any adjustments can be made based on the results seen so far.
- Long-Term Maintenance: After the first follow-up, most patients will benefit from maintenance treatments every few months, depending on their skin type, age, and treatment area. These sessions help to refresh the results and support the ongoing regeneration process.
- Continual Assessment: During follow-up visits, healthcare professionals can assess the effectiveness of the treatment and adjust the regimen if necessary. If the patient has made significant progress, the frequency of treatments may be reduced.
Scheduled follow-up appointments ensure that the results are maintained and that patients continue to experience the long-term benefits of the polynucleotide treatment.
Managing Patient Expectations
Patients should have realistic expectations for polynucleotide treatments, as results are initially gradual and subtle. After treatment, mild redness, swelling, or bruising may occur, resolving within a few days. Initial hydration and skin texture improvements are visible within weeks.
Full results appear 2-3 months later, with firmer, smoother skin. Over time, the benefits continue but will gradually diminish, making follow-up treatments essential. Clear communication about the gradual nature of results helps manage patient expectations and satisfaction.
Conclusion
A well-structured polynucleotide treatment regimen typically begins with three to five sessions, tailored to individual skin needs. The frequency and number of treatments may vary, but follow-up sessions are essential for maintaining long-term results. Since improvements develop gradually, setting realistic expectations is key to ensuring patient satisfaction.
By following a personalized approach, healthcare professionals can maximize the benefits of polynucleotide treatments, helping patients achieve smoother, firmer, and more rejuvenated skin over time.
FAQs
1. What are polynucleotides?
Polynucleotides are long chains of nucleotides that play a key role in various regenerative processes, including collagen production and skin healing.
2. What conditions can polynucleotides treat?
They are commonly used for skin rejuvenation, wound healing, hair loss treatment, and improving skin elasticity and texture.
3. How many treatments will patients need for optimal results?
Typically, they need 3-5 sessions. Practitioners may adjust the frequency based on the patient’s needs, skin condition, and treatment area.
4. How soon will I see results from polynucleotide treatments?
Initial skin texture and hydration improvements can be seen within 1-2 weeks, with full results visible after 2-3 months.
References
Rod Rohrich MD, Friday J 16. Breaking down the most popular noninvasive cosmetic treatments. American Society of Plastic Surgeons. Published June 16, 2017. https://www.plasticsurgery.org/news/blog/breaking-down-the-most-popular-noninvasive-cosmetic-treatments
Reuther T, Bayrhammer J, Kerscher M. Effects of a three-session skin rejuvenation treatment using stabilized hyaluronic acid-based gel of non-animal origin on skin elasticity: a pilot study. Archives of Dermatological Research. 2009;302(1):37-45. doi:https://doi.org/10.1007/s00403-009-0988-9
Vedamurthy M, Duvvuru V, Chelikani VL. Skin boosters – The upcoming boom in cosmetic dermatology for healthy skin. Cosmoderma. 2023;3. doi:https://doi.org/10.25259/CSDM_93_2023