Radiesse Vs Juvederm Voluma: Which is the Best Dermal Filler?

Radiesse and Juvederm Voluma are FDA-approved dermal fillers for moderate to severe facial wrinkles and folds, including the nasolabial folds. Although both are known for their excellent lifting effect, they contain different materials, and as such, have different mechanisms of action.

Juvederm Voluma was the first facial filler approved specifically for age-related volume loss in the cheeks (cheek augmentation). Radiesse was the first dermal filler to be approved for treating areas other than the face. It corrects volume loss in the backs of the hands (hand augmentation). For off-label uses, these products are also consistently being used for marionette lines and facial contouring.

Advantages of Radiesse

  • It stimulates the production of new collagen.
  • Its synthetic polymer component is not easily degraded by the body, which means its effects last longer than HA-based fillers.
  • It can be used for hand rejuvenation.
  • Its scaffolding-like structure supports the skin.

Advantages of Juvederm Voluma

  • It’s approved for cheek augmentation.
  • It has a variant that contains lidocaine, avoiding the need for topical numbing creams.
  • It is specially formulated using Vycross Technology—improved cross-linking efficiency of hyaluronic acid (HA) by combining high and low molecular weight HA.
  • It attracts more water than Radiesse because of its HA component.
  • Overcorrection or undesirable effects can be reversed to some level.

Radiesse vs Juvederm Voluma





Calcium hydroxylapatite microspheres

Crosslinked Hyaluronic acid

Safety Profile

Generally safe, but can be more prone to complications, such as nodule or bump formation.

Post-injection reactions (redness, swelling, tenderness, and bruising) are common.


Provides great lifting effect and is good for correcting deeper lines.

Adds volume to the cheeks.


$600 to $800

$700 to $1,000


Lasts up to 2 years.

Lasts between 6 to 12 months.