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Hymovis
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Last Updated On November 25, 2024

Hymovis Prescribing Information for Practitioners

Nov 22, 2024

Viscosupplements are widely prescribed for osteoarthritis, benefiting millions of patients by relieving pain and improving joint function. These treatments, which include hyaluronic acid injections, work by lubricating and cushioning the joints, significantly easing osteoarthritis symptoms and enhancing mobility.

Hymovis is a leading viscosupplement specifically formulated to address knee pain caused by osteoarthritis. It is often recommended for patients who have not found relief with other arthritis treatments. Its unique formulation ensures long-lasting relief, making it a valuable option for managing osteoarthritis symptoms.

This article provides a comprehensive guide for practitioners on the Hymovis prescribing information, including proper dosage, administration techniques, and potential side effects.

Key Takeaways

  • Hymovis is a viscosupplement designed to relieve knee osteoarthritis pain and improve mobility.
  • The recommended dosage involves two 3 mL injections spaced one week apart, providing up to six months of symptom relief.
  • Contraindications include allergies to hyaluronan, infections near the injection site, and certain medical conditions like bleeding disorders.
  • Hymovis offers long-lasting pain relief due to its advanced HYADD®4 formulation, which enhances joint lubrication and shock absorption.
  • Managing side effects involves basic measures such as applying ice packs, rest, and maintaining cleanliness at the injection site.
  • Patient suitability depends on overall health, the severity of osteoarthritis, and prior responses to first-line treatments.
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Hymovis is an intra-articular injection that can treat knee osteoarthritis. The recommended dosage is two injections of 3 mL each, spaced one week apart. This regimen provides long-lasting pain relief and improved joint mobility, often for up to six months.

right dose of medication

Administration Technique

  • A healthcare professional should administer the injection directly into the synovial space of the knee joint under aseptic conditions.
  • Before injecting Hymovis, any effusion present in the knee should be aspirated to ensure optimal effectiveness. This process can be done with an 18-20 gauge needle.
  • To minimize the risk of infection, experts should perform the treatment using standard intra-articular injection site preparation and strict aseptic techniques.

Contraindications, Warnings, and Precautions

Before administering Hymovis for knee osteoarthritis, practitioners should consider contraindications and precautions to ensure patient safety:

  • Allergy to Hyaluronan: Patients allergic to the Hymovis injection ingredients like hyaluronan or bacterial fermentation products should not receive Hymovis.
  • Infection: Avoid injection if there is a knee infection, open wound, or skin condition near the site, as this may worsen the infection.
  • Pregnancy & Breastfeeding: Hymovis is not recommended due to insufficient safety data for pregnant or breastfeeding women.
  • Pediatric Use: It is not approved for patients under 18 years old.
  • Bleeding Disorders: Doctors should exercise caution before administering the treatment in patients with bleeding problems, as intra-articular injections may increase the risk of bleeding.
  • Knee Malformation: Structural abnormalities or severe muscle weakness may affect the distribution and efficacy of Hymovis.
  • Sterile Technique: Ensuring a clean injection site is critical to minimize infection risks.
  • Monitoring Side Effects: Healthcare providers should inform their patients about potential side effects, including swelling or discomfort at the injection site, which typically resolve within days.

Patient Selection Criteria and Expected Outcomes

Hymovis is an effective treatment option for knee osteoarthritis (OA), particularly for patients who have not experienced sufficient relief from first-line therapies such as physical therapy, oral analgesics, or nonsteroidal anti-inflammatory drugs (NSAIDs). It is specifically recommended for individuals with mild to moderate OA who seek to alleviate joint pain and stiffness.

patient's knee checkup

Ideal candidates for Hymovis include those without active knee infections, significant structural abnormalities, or known allergies to hyaluronan. Patients with bleeding disorders or those on anticoagulants should undergo careful evaluation to ensure the treatment’s safety. By focusing on the patient’s overall health and condition, healthcare providers can identify individuals most likely to benefit from the therapy.

Hymovis delivers long-lasting pain relief, with benefits often extending up to six months after completing its two-dose injection regimen. Thanks to its advanced HYADD®4 formulation, the treatment enhances the viscoelastic properties of synovial fluid, improving shock absorption and reducing joint friction. Many patients report significant reductions in knee pain and stiffness, leading to better mobility and improved performance in daily activities.

To optimize outcomes, it is essential to set realistic expectations. While Hymovis effectively alleviates symptoms, it does not reverse cartilage damage or cure osteoarthritis. Patients should understand that individual results may vary, with some experiencing noticeable relief within weeks and others requiring additional time for improvement.

Encouraging patients to follow a comprehensive OA management plan can further enhance the benefits of Hymovis. Recommendations may include weight management, low-impact exercises, and adherence to post-treatment guidelines. Regular follow-up appointments allow monitoring progress, addressing concerns, and ensuring alignment with the patient’s treatment goals, resulting in greater satisfaction and long-term success.

Guidelines for Managing Treatment Side Effects

Managing side effects from Hymovis injections is crucial for ensuring patient comfort and successful outcomes. Although the treatment is generally well-tolerated, minor side effects may occur. Here are guidelines for addressing common reactions:

doctor checks the state of a patient's knee
  • Discomfort at the Injection Site: Apply an ice pack in brief intervals immediately after the injection to reduce pain and swelling.
  • Knee Inflammation: Encourage patients to rest and elevate the leg to minimize swelling.
  • Localized Redness or Swelling: To prevent irritation, maintain cleanliness at the injection site and cover it with a clean bandage if necessary.
  • Joint Stiffness: Recommend gentle, low-impact exercises to improve mobility and reduce stiffness.
  • Mild Skin Irritation: Over-the-counter creams can help soothe minor irritation at the injection site.
  • Temporary Discoloration: Assure patients that bruising or redness is common and typically resolves within a week.
  • Warmth Around the Treated Area: Suggest using a cold compress to alleviate discomfort.

Conclusion

Hymovis injections provide a clinically proven solution for managing knee osteoarthritis pain, particularly for patients unresponsive to first-line treatments. With its advanced formulation, Hymovis delivers significant relief by improving joint lubrication and reducing friction, contributing to better mobility and quality of life. However, practitioners must carefully assess patient suitability, monitor side effects, and set realistic expectations to ensure optimal outcomes.

Combined with a comprehensive osteoarthritis management plan, Hymovis can be an effective option for patients seeking long-term pain relief and improved joint function.

FAQs

1. Can Hymovis cure osteoarthritis?

Hymovis cannot cure osteoarthritis or reverse cartilage damage. It can alleviate symptoms and improve mobility by enhancing joint lubrication.

2. How soon can patients experience relief after Hymovis injections?

Some patients may notice improvements within weeks, while others may take longer to experience significant relief. Results typically last up to six months.

3. Who is not eligible for Hymovis treatment?

Patients with allergies to hyaluronan, active knee infections, or significant structural joint abnormalities are not suitable candidates for Hymovis. It may also not work for individuals under 18, pregnant or breastfeeding women, and those with bleeding disorders.

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References

Viscosupplementation for Osteoarthritis. Accessed November 22, 2024. https://assets.ctfassets.net/plyq12u1bv8a/5D6hhWQpECcNeI2e6VG567/2baa3d83abb82476d2eede90d1afc5e3/CG054_Viscosupplementation_for_Osteoarthritis.pdf 

Mayo Clinic. Knee pain – Symptoms and causes. Mayo Clinic. Published 2019. https://www.mayoclinic.org/diseases-conditions/knee-pain/symptoms-causes/syc-20350849